76674-21-0
Chemical Structure
Flutriafol
- CAS No.: 76674-21-0
- Formula:C16H13F2N3O
- Molecular Weight:301.29
IUPAC Name: 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol
InChIKey: JWUCHKBSVLQQCO-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(F)C=C1)(C2=CC=CC=C2F)CN3N=CN=C3
Biological Activity: Flutriafol is an orally active triazole fungicide. Flutriafol blocks the biosynthesis of ergosterol, cholesterol, and steroids by inhibiting CYP51, thereby inhibiting fungal cell membrane formation and exhibiting antifungal activity. Flutriafol induces oxidative stress, mitochondrial depolarization, and apoptosis in hepatocellular carcinoma cells. Flutriafol also modulates dopamine release and reduces plasma cholesterol, triglycerides, and carotenoid eye ring pigmentation. Flutriafol can be used in research related to fungal infections and non-alcoholic fatty liver disease[1][2][3][4][5][6].
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Flutriafol | 98.02% | Flutriafol is an orally active triazole fungicide. Flutriafol blocks the biosynthesis of ergosterol, cholesterol, and steroids by inhibiting CYP51, thereby inhibiting fungal cell membrane formation and exhibiting antifungal activity. Flutriafol induces oxidative stress, mitochondrial depolarization, and apoptosis in hepatocellular carcinoma cells. Flutriafol also modulates dopamine release and reduces plasma cholesterol, triglycerides, and carotenoid eye ring pigmentation. Flutriafol can be used in research related to fungal infections and non-alcoholic fatty liver disease. | ||||||||||||||||||||
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Flutriafol (Standard) | ≥98% | Flutriafol (Standard) is the analytical standard of Flutriafol (HY-W019852). This product is intended for research and analytical applications. Flutriafol is an orally active triazole fungicide. Flutriafol blocks the biosynthesis of ergosterol, cholesterol, and steroids by inhibiting CYP51, thereby inhibiting fungal cell membrane formation and exhibiting antifungal activity. Flutriafol induces oxidative stress, mitochondrial depolarization, and apoptosis in hepatocellular carcinoma cells. Flutriafol also modulates dopamine release and reduces plasma cholesterol, triglycerides, and carotenoid eye ring pigmentation. Flutriafol can be used in research related to fungal infections and non-alcoholic fatty liver disease. | ||||||||||||||||||||
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References
- [1]. Kwon HC, et al. Effects of Flutriafol Fungicide on the Lipid Accumulation in Human Liver Cells and Rat Liver. Foods (Basel, Switzerland). 2021 Jun 10;10(6):1346.
- [2]. Lopez-Antia A, et al. Brood size is reduced by half in birds feeding on flutriafol-treated seeds below the recommended application rate. Environmental pollution (Barking, Essex : 1987). 2018 Dec;243(Pt A):418-426.
- [3]. Faro LR, et al. Role of ionotropic glutamatergic receptors and nitric oxide in the effects of flutriafol, a triazole fungicide, on the in vivo striatal dopamine release. The Journal of toxicological sciences. 2012;37(6):1135-42. [Content Brief]
- [4]. Ktari N, et al. Integrated UPLC-Q-TOF MS/MS and computational analysis identify antioxidant peptides from Salaria basilisca protein hydrolysate with protection against flutriafol-induced oxidative stress. Results in Chemistry. 2026 Aug 26:103790.
- [5]. Guo H, et al. Synthesis and bacteriostatic activities of modified flutriafol derivatives. ACS Omega. 2019 Jan 31;4(1):9-14.
- [6]. Ktari N, et al. Subacute oral toxicity of flutriafol in mice: Behavioral, biochemical, and histological alterations. Toxicology and industrial health. 2026 Mar;42(3):61-81.
