79770-24-4
Chemical Structure
Iotrolan
- CAS No.: 79770-24-4
- Formula:C37H48I6N6O18
- Molecular Weight:1626.23
IUPAC Name: 5,5'-(malonylbis(methylazanediyl))bis(2,4,6-triiodo-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)isophthalamide)
InChIKey: XUHXFSYUBXNTHU-UHFFFAOYSA-N
SMILES: O=C(N(C1=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C1I)C)CC(N(C2=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C2I)C)=O
Biological Activity: Iotrolan is a non-ionic contrast agent. Iotrolan induces Apoptosis. Iotrolan decreases glomerular filtration rate and renal perfusate flow, increases urine flow, and does not significantly decrease fractional sodium reabsorption. Iotrolan can be used in studies of COVID-19 and contrast-induced nephrotoxicity[1][2][3][4][5][6].
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Iotrolan | Iotrolan is a non-ionic contrast agent. Iotrolan induces Apoptosis. Iotrolan decreases glomerular filtration rate and renal perfusate flow, increases urine flow, and does not significantly decrease fractional sodium reabsorption. Iotrolan can be used in studies of COVID-19 and contrast-induced nephrotoxicity. | |||||||||||||||||||||
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References
- [1]. Kanhed AM, et al. Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach. Molecular diversity. 2021 Feb;25(1):383-401.
- [2]. Oldroyd S, et al. Reduced depression of renal function by iotrolan in the isolated rat kidney. European journal of radiology. 1994 Feb;18(1):64-9.
- [3]. Rosati G, et al. Clinical utility and safety profile of iomeprol. European journal of radiology. 1994 May;18 Suppl 1:S120-4.
- [4]. Fanning NF, et al. Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway. The British journal of radiology. 2002 Nov;75(899):861-73.
- [5]. Heinrich MC, et al. Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro. Radiology. 2005 Jun;235(3):843-9.
- [6]. Vesga LC, et al. Repurposing of four drugs as anti-SARS-CoV-2 agents and their interactions with protein targets. Scientia Pharmaceutica. 2022 Apr 14;90(2):24.
