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Cat. No.: HY-107992

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Iotrolan

Iotrolan is a non-ionic contrast agent. Iotrolan induces Apoptosis. Iotrolan decreases glomerular filtration rate and renal perfusate flow, increases urine flow, and does not significantly decrease fractional sodium reabsorption. Iotrolan can be used in studies of COVID-19 and contrast-induced nephrotoxicity.

For research use only. We do not sell to patients.

CAS No.: 79770-24-4
Formula: C₃₇H₄₈I₆N₆O₁₈
Molecular Weight:1626.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Iotrolan Chemical Structure

CAS No.: 79770-24-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Renal RegulationOthers

Renal Regulation

Iotrolan (0-30 min) in the isolated perfused rat kidney produces a maximum GFR decrease of -24.7% and a maximum renal perfusate flow decrease of -21.7%, while increasing urine flow without a sustained fall in fractional sodium reabsorption^[2].

Others

Iotrolan (18.75-150 mg iodine/mL; 1-24 h) exerts direct cytotoxic effects on LLC-PK1 proximal renal tubular cells, reducing MTT conversion to 41% at 75 mg iodine/mL and to 41-50% at 98.5 mM^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[5]

Cell Line:

LLC-PK1 renal tubular cells
Concentration:

18.75-150 mg iodine/mL; 75 mg iodine/mL; 98.5 mM (equal molarity); 98.5 mM (equimolar comparison)
Incubation Time:

1-24 h
Result:

At 75 mg iodine/mL, MTT conversion was 41% of undamaged control cells.
At equal molarity (98.5 mM), MTT conversion was 41%.
At equimolar concentrations (98.5 mM), MTT conversion was 50%.

Related Protocols :

Chemical Information

CAS No. 79770-24-4
Molecular Weight 1626.23
Formula C₃₇H₄₈I₆N₆O₁₈
SMILES

O=C(N(C1=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C1I)C)CC(N(C2=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C2I)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kanhed AM, et al. Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach. Molecular diversity. 2021 Feb;25(1):383-401.

[2]. Oldroyd S, et al. Reduced depression of renal function by iotrolan in the isolated rat kidney. European journal of radiology. 1994 Feb;18(1):64-9.

[3]. Rosati G, et al. Clinical utility and safety profile of iomeprol. European journal of radiology. 1994 May;18 Suppl 1:S120-4.

[4]. Fanning NF, et al. Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway. The British journal of radiology. 2002 Nov;75(899):861-73.

[5]. Heinrich MC, et al. Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro. Radiology. 2005 Jun;235(3):843-9.

[6]. Vesga LC, et al. Repurposing of four drugs as anti-SARS-CoV-2 agents and their interactions with protein targets. Scientia Pharmaceutica. 2022 Apr 14;90(2):24.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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