83291-91-2
83291-91-2
Chemical Structure
Hemicholinium-3 bromo mustard
Synonym(s): HC3-BrM
- CAS No.: 83291-91-2
- Formula:C24H30Br2N2O4
- Molecular Weight:570.31
InChIKey: DEHLWSSPVQFNBM-UHFFFAOYSA-N
SMILES: BrCCN1CCOC(C2=CC=C(C3=CC=C(C4(OCCN(C4)CCBr)O)C=C3)C=C2)(C1)O
Biological Activity: Hemicholinium‑3 bromo mustard (HC3-BrM) is a nitrogen mustard derivative of hemicholinium-3 (HC-3) and acts as an inhibitor of the sodium-dependent high-affinity choline uptake system. Hemicholinium-3 bromo mustard cyclizes to form a highly reactive bis-aziridinium intermediate. Hemicholinium-3 bromo mustard is used in research on choline transporter-related diseases[1][2].
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Hemicholinium-3 bromo mustard | Hemicholinium‑3 bromo mustard (HC3-BrM) is a nitrogen mustard derivative of hemicholinium-3 (HC-3) and acts as an inhibitor of the sodium-dependent high-affinity choline uptake system. Hemicholinium-3 bromo mustard cyclizes to form a highly reactive bis-aziridinium intermediate. Hemicholinium-3 bromo mustard is used in research on choline transporter-related diseases. | |||||||||||||||||||||
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References
- [1]. Smart L. Hemicholinium 3-bromo mustard: a new high affinity inhibitor of sodium-dependent high affinity choline uptake. Neuroscience. 1981;6(9):1765-70.
- [2]. Tagari PC, et al. Hemicholinium mustard derivatives: preliminary assessment of cholinergic neurotoxicity. Neurochemical research. 1986 Jul;11(7):1091-102.
