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Cat. No.: HY-189039

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Hemicholinium-3 bromo mustard

Name: Hemicholinium-3 bromo mustard
Brand: MedChemExpress
SKU: HY-189039
Availability: PreOrder

(Synonyms: HC3-BrM)

Hemicholinium‑3 bromo mustard (HC3-BrM) is a nitrogen mustard derivative of hemicholinium-3 (HC-3) and acts as an inhibitor of the sodium-dependent high-affinity choline uptake system. Hemicholinium-3 bromo mustard cyclizes to form a highly reactive bis-aziridinium intermediate. Hemicholinium-3 bromo mustard is used in research on choline transporter-related diseases.

For research use only. We do not sell to patients.

CAS No.: 83291-91-2
Formula: C₂₄H₃₀Br₂N₂O₄
Molecular Weight:570.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hemicholinium-3 bromo mustard Chemical Structure

CAS No.: 83291-91-2

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Biological Activity

Description

In Vitro

Hemicholinium‑3 bromo mustard (HC3-BrM) generates active bis‑aziridinium intermediate which potently inhibits sodium‑dependent high‑affinity choline uptake (HACU) in rat striatal synaptosomes, with an inhibition rate exceeding 80%; washing to remove free drug still leaves a stable 32‑34% inhibitory effect; quenching its active intermediate with sodium thiosulfate completely eliminates the compound’s HACU inhibitory effect^[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 83291-91-2
Molecular Weight 570.31
Formula C₂₄H₃₀Br₂N₂O₄
SMILES

BrCCN1CCOC(C2=CC=C(C3=CC=C(C4(OCCN(C4)CCBr)O)C=C3)C=C2)(C1)O
Synonyms

HC3-BrM
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Smart L. Hemicholinium 3-bromo mustard: a new high affinity inhibitor of sodium-dependent high affinity choline uptake. Neuroscience. 1981;6(9):1765-70.

[2]. Tagari PC, et al. Hemicholinium mustard derivatives: preliminary assessment of cholinergic neurotoxicity. Neurochemical research. 1986 Jul;11(7):1091-102.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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