870193-55-8
Chemical Structure
Erinacerin B
- CAS No.: 870193-55-8
- Formula:C19H24O5
- Molecular Weight:332.40
IUPAC Name: (S,E)-4-hydroxy-5-(5-hydroxy-3,7-dimethylocta-2,6-dien-1-yl)-6-methoxyisobenzofuran-1(3H)-one
InChIKey: IEEOEOCAXCAZFD-YQJFHSMKSA-N
SMILES: OC1=C2C(=CC(OC)=C1C/C=C(/C[C@@H](C=C(C)C)O)\C)C(=O)OC2
Biological Activity: Erinacerin B is an isoindolinone skeleton compound. Erinacerin B is present in the mycelia and fruiting bodies of Hericium erinaceus. Erinacerin B inhibits NF-κB (p65 subunit) and AP-1 (c-Jun subunit). Erinacerin B inhibits LPS-induced nitric oxide and Prostaglandin E2 (HY-101952) production. Erinacerin B attenuates neuroinflammation. Erinacerin B is used in research on neurodegenerative and inflammatory diseases[1][2][3][4].
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Erinacerin B | Erinacerin B is an isoindolinone skeleton compound. Erinacerin B is present in the mycelia and fruiting bodies of Hericium erinaceus. Erinacerin B inhibits NF-κB (p65 subunit) and AP-1 (c-Jun subunit). Erinacerin B inhibits LPS-induced nitric oxide and Prostaglandin E2 (HY-101952) production. Erinacerin B attenuates neuroinflammation. Erinacerin B is used in research on neurodegenerative and inflammatory diseases. | |||||||||||||||||||||
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References
- [1]. Thongkongkaew T, et al. Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2, 3-Dihydroxy-4-(hydroxymethyl) tetrahydrofuran-1-yl]-pyridine-4, 5-diol. ACS omega. 2023 Nov 21;8(48):46284.
- [2]. Noh HJ, et al. Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells. Journal of enzyme inhibition and medicinal chemistry. 2015 Dec;30(6):934-40. [Content Brief]
- [3]. Lin JY, et al. Discovery of a new compound, erinacerin W, from the mycelia of Hericium erinaceus, with immunomodulatory and neuroprotective effects. Molecules. 2024 Feb 9;29(4):812. [Content Brief]
- [4]. Noh HJ, et al. Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF-κB and AP-1 activity. Immunopharmacology and immunotoxicology. 2014 Oct;36(5):349-54. [Content Brief]
