Erinacerin B
Erinacerin B is an isoindolinone skeleton compound. Erinacerin B is present in the mycelia and fruiting bodies of Hericium erinaceus. Erinacerin B inhibits NF-κB (p65 subunit) and AP-1 (c-Jun subunit). Erinacerin B inhibits LPS-induced nitric oxide and Prostaglandin E2 (HY-101952) production. Erinacerin B attenuates neuroinflammation. Erinacerin B is used in research on neurodegenerative and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 870193-55-8
- Formula: C19H24O5
- Molecular Weight:332.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Fungal Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
67.36 μM
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Inhibition of nitric oxide production in LPS-stimulated RAW264.7 macrophage cells pre-treated for 30 mins followed by incubation with LPS for 24 hrs measured by Griess reagent.
Inhibition of nitric oxide production in LPS-stimulated RAW264.7 macrophage cells pre-treated for 30 mins followed by incubation with LPS for 24 hrs measured by Griess reagent.
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25090632 |
| RAW264.7 | IC50 |
60.10 μM
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Inhibition of prostaglandin E2 production in LPS-stimulated RAW264.7 macrophage cells pre-treated for 30 mins followed by incubation with LPS for 24 hrs measured by Griess reagent.
Inhibition of prostaglandin E2 production in LPS-stimulated RAW264.7 macrophage cells pre-treated for 30 mins followed by incubation with LPS for 24 hrs measured by Griess reagent.
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25090632 |
In Vitro
Erinacerin B (1-10 μg/mL; 3 days) does not inhibit cellular senescence in HDFs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVECs
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Concentration:1, 10 μg/mL
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Incubation Time:3 days
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Result:Did not show cytotoxicity at 10 μg/mL.
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Cell Line:HDFs
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Concentration:1, 10 μg/mL
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Incubation Time:3 days
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Result:Did not show cytotoxicity at 10 μg/mL.
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Cell Line:RAW264.7
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Concentration:100 μM
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Incubation Time:30 min and 60 min
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Result:Blocked the phosphorylation of NF-κB and AP-1 in a time-dependent manner.
Significantly reduced the abundance of LPS-induced phospho-c-Jun at 30 min.
Significantly reduced the abundance of LPS-induced phospho-p65 at 60 min.
Chemical Information
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CAS No. 870193-55-8
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Molecular Weight 332.40
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Formula C19H24O5
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SMILES
OC1=C2C(=CC(OC)=C1C/C=C(/C[C@@H](C=C(C)C)O)\C)C(=O)OC2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Noh HJ, et al. Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells. Journal of enzyme inhibition and medicinal chemistry. 2015 Dec;30(6):934-40. [Content Brief]
[3]. Lin JY, et al. Discovery of a new compound, erinacerin W, from the mycelia of Hericium erinaceus, with immunomodulatory and neuroprotective effects. Molecules. 2024 Feb 9;29(4):812. [Content Brief]
[4]. Noh HJ, et al. Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF-κB and AP-1 activity. Immunopharmacology and immunotoxicology. 2014 Oct;36(5):349-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Erinacerin B Related Classifications
HY-N21647 Related Classifications
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