879292-24-7
Chemical Structure
Silodosin Glucuronide sodium
Synonym(s): Silodosin β-D-glucuronide sodium; KMD-3213G sodium
- CAS No.: 879292-24-7
- Formula:C31H39F3N3NaO10
- Molecular Weight:693.64
IUPAC Name: (9Z,11E,13E)-octadeca-9,11,13-trienoic acid
InChIKey: SSXDGVSHJRFUEJ-XNUWQVEGSA-M
SMILES: O=C(O[Na])[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OCCCN2C3=C(C(N)=O)C=C(C[C@@H](C)NCCOC4=C(C=CC=C4)OCC(F)(F)F)C=C3CC2
Biological Activity: Silodosin Glucuronide (Silodosin β-D-glucuronide; KMD-3213G) sodium is generated in vivo via glucuronidation of the α1A-adrenoceptor antagonist Silodosin (HY-10122). Silodosin Glucuronide sodium is a key biomarker measured simultaneously with the parent drug in human pharmacokinetic/bioequivalence studies of Silodosin formulations[1][2].
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Silodosin Glucuronide sodium | Silodosin Glucuronide (Silodosin β-D-glucuronide; KMD-3213G) sodium is generated in vivo via glucuronidation of the α1A-adrenoceptor antagonist Silodosin (HY-10122). Silodosin Glucuronide sodium is a key biomarker measured simultaneously with the parent drug in human pharmacokinetic/bioequivalence studies of Silodosin formulations. | |||||||||||||||||||||
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References
- [1]. Shah PA, et al. Determination of silodosin and its active glucuronide metabolite KMD-3213G in human plasma by LC-MS/MS for a bioequivalence study. Biomedical chromatography : BMC. 2018 Feb;32(2).
- [2]. Schilit S, et al. Silodosin: A Selective α1A-Adrenergic Receptor Antagonist for the Treatment of Benign Prostatic Hyperplasia. Clinical Therapeutics. 2009, 31 (11): 2310-2322.
