884320-54-1
884320-54-1
Chemical Structure
3-Iodothyronamine-d4 hydrochloride
- CAS No.: 884320-54-1
- Formula:C14H11D4ClINO2
- Molecular Weight:395.66
IUPAC Name: 4-(4-(2-aminoethyl-1,1,2,2-d4)-2-iodophenoxy)phenol hydrochloride
InChIKey: RVKVVMXTPQCCIX-UVSTZUAESA-N
SMILES: OC1=CC=C(OC2=CC=C(C([2H])([2H])C([2H])([2H])N)C=C2I)C=C1.[H]Cl
Biological Activity: 3-Iodothyronamine-d4 (hydrochloride) is the deuterium labeled 3-Iodothyronamine hydrochloride[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Iodothyronamine-d4 hydrochloride | 98.85% | 3-Iodothyronamine-d4 (hydrochloride) is the deuterium labeled 3-Iodothyronamine hydrochloride. | ||||||||||||||||||||
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3-Iodothyronamine hydrochloride-13C6 | 3-Iodothyronamine hydrochloride-13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure. | |||||||||||||||||||||
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3-Iodothyronamine hydrochloride | 99.5% | 3-Iodothyronamine (hydrochloride) is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure. | ||||||||||||||||||||
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T2AA | 99.04% | T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase. | ||||||||||||||||||||
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T2AA hydrochloride | T2AA hydrochloride is a non-peptide small molecule PCNA inhibitor T2 amino alcohol (T2AA) that lacks thyroid hormone activity. T2AA hydrochloride inhibits the interaction of PCNA/PIP-box peptide (IC50=~1 μM) and the interaction of PCNA with full-length p21 protein. | |||||||||||||||||||||
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NSC 90469 | 99.41% | NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity. | ||||||||||||||||||||
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3,5-Diiodothyroacetic acid | 3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research. | |||||||||||||||||||||
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3,5-Diiodothyropropionic acid (Standard) | ≥98% | 3,5-Diiodothyropropionic acid (Standard) is the analytical standard of 3,5-Diiodothyropropionic acid. This product is intended for research and analytical applications. 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure. | ||||||||||||||||||||
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3,3'-Diiodo-L-thyronine-13C6 | 3,3'-Diiodo-L-thyronine-13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. | |||||||||||||||||||||
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3-Iodo-L-thyronine-13C6 | 3-Iodo-L-thyronine-13C6 is the 13C-labeled 3-Iodo-L-thyronine (HY-W588264). 3-Iodo-L-thyronine (3-Monoiodothyronine) is an endogenous iodothyronine thyroid hormone metabolite. 3-Iodo-L-thyronine can be used for research on differentiated thyroid cancer. | |||||||||||||||||||||
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3-Iodo-L-thyronine | 99.79% | 3-Iodo-L-thyronine (3-Monoiodothyronine) is an endogenous iodothyronine thyroid hormone metabolite. 3-Iodo-L-thyronine can be used for research on differentiated thyroid cancer. | ||||||||||||||||||||
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