897026-25-4
Chemical Structure
Azurin p28 peptide
- CAS No.: 897026-25-4
- Formula:C122H197N31O47S2
- Molecular Weight:2914.18
SMILES: C([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CO)=O)[C@@H](C)O)=O)C)=O)C)=O)CC(O)=O)=O)CCSC)=O)CCC(N)=O)=O)=O)[C@H](C)C)=O)[C@H](C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)CCSC)=O)C)=O)CO)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)CC(C)C)=O)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(O)=O)=O)CCC2
Biological Activity: Azurin p28 peptide is a cell-penetrating peptide derived from the copper-containing oxidoreductase azurin of Pseudomonas aeruginosa, possessing antitumor and anti-angiogenic activities. Azurin p28 peptide can selectively enter tumor cells as a cell-penetrating peptide, block the interaction between COP1 and p53, inhibit p53 degradation, and elevate intracellular p53 protein levels. Azurin p28 peptide can induce tumor cell apoptosis. Azurin p28 peptide can be used in cancer-related research, such as breast cancer and central nervous system tumors[1][2][3].
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Azurin p28 peptide | 99.36% | Azurin p28 peptide is a cell-penetrating peptide derived from the copper-containing oxidoreductase azurin of Pseudomonas aeruginosa, possessing antitumor and anti-angiogenic activities. Azurin p28 peptide can selectively enter tumor cells as a cell-penetrating peptide, block the interaction between COP1 and p53, inhibit p53 degradation, and elevate intracellular p53 protein levels. Azurin p28 peptide can induce tumor cell apoptosis. Azurin p28 peptide can be used in cancer-related research, such as breast cancer and central nervous system tumors. | ||||||||||||||||||||
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References
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[1]. Baindara P, et al. Bacteriocins: perspective for the development of novel anticancer drugs. Applied microbiology and biotechnology. 2018 Dec;102(24):10393-10408.
[Content Brief] - [2]. Goh KS, et al. A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies. International Journal of Peptide Research and Therapeutics. 2022 Mar;28(2):75.
- [3]. Zhang H, et al. Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules. Pharmaceutics. 2023 Aug 07;15(8):2093.
