90597-20-9
Chemical Structure
Cyclopentenyl uracil
- CAS No.: 90597-20-9
- Formula:C10H12N2O5
- Molecular Weight:240.22
InChIKey: FCWVOJUKQSHZIV-VDAHYXPESA-N
SMILES: O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])C=C([C@H]1O)CO
Biological Activity: Cyclopentenyl uracil is a non-cytotoxic Uridine-Cytidine Kinase inhibitor and an antagonist of EIDD-1931 (NHC) (HY-125033) bioactivation. Cyclopentenyl uracil blocks NHC phosphorylation by inhibiting UCK1/UCK2, reduces intracellular NHC-TP accumulation, and depletes UTP/CTP pools, thereby antagonizing the antiviral activity of NHC and inhibiting dengue virus replication. Cyclopentenyl uracil is used in research on SARS-CoV-2 infection, dengue virus infection, leukemia, and solid tumors[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclopentenyl uracil | 99.84% | Cyclopentenyl uracil is a non-cytotoxic Uridine-Cytidine Kinase inhibitor and an antagonist of EIDD-1931 (NHC) (HY-125033) bioactivation. Cyclopentenyl uracil blocks NHC phosphorylation by inhibiting UCK1/UCK2, reduces intracellular NHC-TP accumulation, and depletes UTP/CTP pools, thereby antagonizing the antiviral activity of NHC and inhibiting dengue virus replication. Cyclopentenyl uracil is used in research on SARS-CoV-2 infection, dengue virus infection, leukemia, and solid tumors. | ||||||||||||||||||||
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References
- [1]. Shu H, et al. Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity. PLoS pathogens. 2026 May;22(5):e1014225. [Content Brief]
- [2]. Shu H, et al. Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation. bioRxiv. 2025 May 14:2025-05. [Content Brief]
- [3]. Politi PM, et al. Phase I clinical trial of continuous infusion cyclopentenyl cytosine. Cancer chemotherapy and pharmacology. 1995;36(6):513-23. [Content Brief]
- [4]. Liu Q, et al. Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism. Cell chemical biology. 2020 Jun 18;27(6):668-677.e9. [Content Brief]
- [5]. Marquez VE, et al. Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. Annals of the New York Academy of Sciences. 2005 Nov;1058(1):246-54. [Content Brief]
- [6]. Cysyk RL, et al. Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo. Biochemical pharmacology. 1995 Jan 18;49(2):203-7. [Content Brief]
- [7]. Ford H, et al. Reversal by cytidine of cyclopentenyl cytosine-induced toxicity in mice without compromise of antitumor activity. Biochemical pharmacology. 1995 Jan 18;49(2):173-80. [Content Brief]
- [8]. Walter M, et al. Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy. Cells. 2022 Feb 20;11(4):739.
