910138-96-4
Chemical Structure
(R)-Duloxetine hydrochloride
Synonym(s): LY248686 hydrochloride
- CAS No.: 910138-96-4
- Formula:C18H20ClNOS
- Molecular Weight:333.88
IUPAC Name: (R)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride
InChIKey: BFFSMCNJSOPUAY-UNTBIKODSA-N
SMILES: CNCC[C@H](C1=CC=CS1)OC2=CC=CC3=C2C=CC=C3.Cl
Biological Activity: (R)-Duloxetine hydrochloride ((R)-LY248686 hydrochloride) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine hydrochloride blocks Na+ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine hydrochloride alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine hydrochloride exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine hydrochloride can be used for research on postoperative (post-incisional) pain[1].
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(R)-Duloxetine hydrochloride | (R)-Duloxetine hydrochloride ((R)-LY248686 hydrochloride) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine hydrochloride blocks Na+ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine hydrochloride alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine hydrochloride exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine hydrochloride can be used for research on postoperative (post-incisional) pain. | |||||||||||||||||||||
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