944834-43-9
Chemical Structure
6-PhEt-ATP-γ-S
Synonym(s): N6-(Phenethyl)-ATPγS
- CAS No.: 944834-43-9
- Formula:C18H24N5O12P3S
- Molecular Weight:627.40
InChIKey: OELVQXUZKRVGOJ-SCFUHWHPSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(O)(OP(S)(O)=O)=O)=O)O[C@H]1N2C=NC3=C(NCCC4=CC=CC=C4)N=CN=C32
Biological Activity: 6-PhEt-ATP-γ-S (N6-(Phenethyl)-ATPγS) is a bulky ATP analog probe carrying a thiophosphate group. 6-PhEt-ATP-γ-S, as an orthogonal phosphate donor, is specifically utilized by mutant-sensitive kinases such as CDK12-AS and Slt2-as to label their direct substrate proteins. 6-PhEt-ATP-γ-S specifically binds to the enlarged pocket of mutant kinases via its bulky side chain (avoiding wild-type), and covalently labels substrates through thiophosphorylation. 6-PhEt-ATP-γ-S can be used for kinase-substrate profiling studies[1][2].
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6-PhEt-ATP-γ-S | 6-PhEt-ATP-γ-S (N6-(Phenethyl)-ATPγS) is a bulky ATP analog probe carrying a thiophosphate group. 6-PhEt-ATP-γ-S, as an orthogonal phosphate donor, is specifically utilized by mutant-sensitive kinases such as CDK12-AS and Slt2-as to label their direct substrate proteins. 6-PhEt-ATP-γ-S specifically binds to the enlarged pocket of mutant kinases via its bulky side chain (avoiding wild-type), and covalently labels substrates through thiophosphorylation. 6-PhEt-ATP-γ-S can be used for kinase-substrate profiling studies. | |||||||||||||||||||||
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References
- [1]. Qiu M, et al. CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. Science advances. 2023 May 19;9(20):eadf8698.
- [2]. Alonso-Rodríguez E, et al. An Analog-sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway. The Journal of biological chemistry. 2016 Mar 11;291(11):5461-5472.
