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Cat. No.: HY-N21732

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Dihydrocucurbitacin E

Dihydrocucurbitacin E is a cucurbitacin anticancer agent found in the rhizomes of Begonia nantoensis. Dihydrocucurbitacin E exhibits cytotoxic effects on gastric cancer cells and nasopharyngeal carcinoma cells. Dihydrocucurbitacin E can be used in research on gastric cancer and nasopharyngeal carcinoma.

For research use only. We do not sell to patients.

CAS No.: 28973-67-3
Formula: C₃₂H₄₆O₈
Molecular Weight:558.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dihydrocucurbitacin E Chemical Structure

CAS No.: 28973-67-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
NUGC-3	IC50	8.60 μg/mL	Cytotoxic activity against human NUGC-3 gastric carcinoma cells measured by cytotoxicity assay. Cytotoxic activity against human NUGC-3 gastric carcinoma cells measured by cytotoxicity assay.	14993759
HONE1 cell line	IC50	2.68 μg/mL	Cytotoxic activity against human HONE-1 nasopharyngeal carcinoma cells measured by cytotoxicity assay. Cytotoxic activity against human HONE-1 nasopharyngeal carcinoma cells measured by cytotoxicity assay.	14993759

In Vitro

Anti-cancer

Dihydrocucurbitacin E (up to 20 μg/mL) is cytotoxic to human NUGC-3 gastric carcinoma and HONE-1 nasopharyngeal carcinoma cells, with IC₅₀ values of 8.60 μg/mL and 2.68 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 28973-67-3
Molecular Weight 558.71
Formula C₃₂H₄₆O₈
SMILES

C[C@]12[C@@](C)([C@@]([C@@](C(CCC(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C=C(O)C(=O)C4(C)C)[H])[H]
Structure Classification
- Terpenoids
- Tetracyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu PL, et al. Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis. Chemical & pharmaceutical bulletin. 2004 Mar;52(3):345-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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