DOBAQ
Based on 1 Customer Validation
DOBAQ is a synthetic pH-sensitive zwitterionic lipid and cationic lipid nanoparticle component. DOBAQ can be used for siRNA delivery and mRNA delivery research.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 1360461-69-3
- Formula: C49H83NO6
- Molecular Weight:782.19
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
GUVs containing DOBAQ (60 mol% DOBAQ; 24 h) mediate lysosomal escape and release the HPTS cargo into the REF cytoplasm[1].
GUVs containing DOBAQ (60 mol% DOBAQ; 24 h) release HPTS cargo into the soma and dendrites of primary mouse hippocampal neurons[1].
GUVs containing DOBAQ (BV:SUV 1:100; 24 h) deliver BV cargo into the REF cytoplasm and support BV-encoded mito-dsRed expression[1].
SAM-cLNPs based on DOBAQ (4-8 mg/mL lipid; 1 h) are monodisperse 66-77 nm particles with near-neutral zeta potential and 85% SAM encapsulation efficiency[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (female, 6-8 weeks old)[3]
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Dosage:siRNA 5 mg/kg; 15:1 w:w ZL:siRNA; 200 µl total volume
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Administration:i.v. tail vein injection; single administration
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Result:DOBAQ-containing ZL-siRNA formulations mediated siRNA-mediated Factor VII knockdown in CD-1 mice.
Chemical Information
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CAS No. 1360461-69-3
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Appearance Solid-Liquid Mixture
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Molecular Weight 782.19
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Formula C49H83NO6
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Color Off-white to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)CC1=CC=C(C=C1)C([O-])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 2.5 mg/mL (3.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2785 mL | 6.3923 mL | 12.7846 mL | 31.9615 mL |
DOBAQ Related Classifications
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