Cancer Analysis Dyes

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.

FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.

MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm.

MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and research. MHI-148 is immediately taken up and accumulated by lysosomes and mitochondria of tumor cells, but not in lysosomes and mitochondria of normal cells.

Isosulfan blue is a blue dye for the identification of lymph vessels during lymphangiography. Isosulfan blueis is used during sentinel lymph node biopsies in breast cancer. Isosulfan blue is possible to have an allergic reaction during breast cancer operations.

CX-P is a tumor-targeting, polarity-specific near-infrared fluorescent probe based on a coumarin-xanthene scaffold. When CX-P is used for cell imaging, Ex/Em = 560/650-750 nm; when used for in vivo imaging in mice, Ex/Em = 560/625-725 nm. CX-P exhibits photostability and low cytotoxicity. CX-P selectively accumulates in HeLa and 4T1 tumor cells via biotin receptors and produces strong red fluorescence, while the fluorescence signal is weak in normal cells. CX-P can monitor intracellular polarity changes in tumor cells and demonstrates tumor-targeting capability in live imaging of tumor-bearing mice. CX-P can be used for cancer-related research.

CH1055-PEG is a water-soluble PEG-modified second near-infrared (NIR-II) small-molecule fluorescent dye. CH1055-PEG can be used in studies such as in vivo fluorescence imaging, tumor-targeted tracing, lymph node imaging, and image-guided surgery (λ_Abs/λ_em : 750/1055 nm).

Zinc phthalocyanine (ZnPc) is commonly applied in industry (catalysts, photoconductors) and biomedical (photodynamic therapy, PDT). Zinc phthalocyanine can be used to photooxidise cyclohexane and is promising for research of solar-cell applications.

Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm.

S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents.

Hexaminolevulinate (Hexyl 5-aminolevulinate) hydrochloride, a porphyrin precursor, is a photosensitiser that can be used in photodynamic therapy (PDT) for certain tumor. Hexaminolevulinate hydrochloride can improve the visualisation of bladder tumours.

Indigo carmine is an efficient reagent for the determination of ozone by chemlluminescence (CL).

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine (SAPE) is a fluorescent reporter that specifically binds biotin. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine produces a detectable fluorescent signal to quantify target factors. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine can be used for the research of primary liver cancer, cervical cancer.

Nilotinib Acid, an analogue of Nilotinib, is usually used as a labeled chemical or fluorescent probe.

CLR1501, a fluorescently labeled CLR1404 analog, is a cancer cell-selective fluorescence compound.

GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a K_d of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors.

Imatinib Acid is an analogue of Imatinib (HY-15463).

Antitumor agent-31 is a nanosized chelates of anchoring bisazo dye. Antitumor agent-31 can be used for an antioxidant and antitumor agent.

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers.