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Cat. No.: HY-187334

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EGFR-IN-216

EGFR-IN-216 is an epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor. EGFR-IN-216 inhibits EGFR tyrosine kinase phosphorylation, blocks downstream signaling pathway activation, suppresses cancer cell proliferation and promotes tumor cell apoptosis (apoptosis). EGFR-IN-216 can be used for the research of non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 1923767-20-7
Formula: C₂₃H₂₆ClF₂N₃O₅
Molecular Weight:497.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-216 Chemical Structure

CAS No.: 1923767-20-7

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All EGFR Isoforms :

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

In Vitro

Anti-cancer

EGFR-IN-216 (MPGF) (0.01-40 μM; 48 h) potently inhibits the viability of PC-9, a non-small cell lung cancer cell line carrying the EGFR exon 19 deletion mutation, with an IC₅₀ of 2.5938 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC-9 cells
Concentration:

0.01, 0.1, 1.25, 2.5, 5, 10, 20, 30, 40 μM
Incubation Time:

48 h
Result:

Potently inhibited the viability of PC-9 cells, with an IC₅₀ of 2.5938 μM, showing a statistically significant inhibitory effect.

Related Protocols :

Chemical Information

CAS No. 1923767-20-7
Molecular Weight 497.92
Formula C₂₃H₂₆ClF₂N₃O₅
SMILES

FC1=CC=C(NC2=C3C=C(OC)C(OCCOCCOCCOCCF)=CC3=NC=N2)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shen Baozhong, et al. Epidermal growth factor receptor tyrosine kinase inhibitors MPGF and MPGH with anti-tumor activity and preparation method and application thereof. CN105541736A. 2017-09-12

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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EGFR-IN-216

All EGFR Isoforms

All Bcr-Abl Isoforms