Epibatidine dihydrochloride
Based on 1 Customer Validation
Epibatidine dihydrochloride is a potent neuronal nicotinic acetylcholine receptor (nAChR) activator. Epibatidine dihydrochloride induces endoplasmic reticulum calcium release through activation of nAChR, which in turn activates the PKC/ERK/HO-1 signaling axis, exerting anti-apoptotic effects by inhibiting ROS production and attenuating mitochondrial depolarization. Epibatidine dihydrochloride can be used in research on neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity : 99%
- CAS No.: 166374-43-2
- Formula: C11H15Cl3N2
- Molecular Weight:281.61
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
ERK1 |
ERK2 |
HO-1 |
Caspase-3 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:bovine chromaffin cells
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Concentration:3, 30, 300, 3000 nM
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Incubation Time:24 h
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Result:Concentration-dependently reduced rotenone/oligomycin-induced cell death, reaching maximum cytoprotection (about 45% reduction in cell death) at 3 μM.
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Cell Line:bovine chromaffin cells
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Concentration:3 μM
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Incubation Time:15 min (for ERK); 24 h (for HO-1 and )
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Result:Significantly induced the phosphorylation of ERK1/2 at 15 min.
Increased the protein expression of HO-1 by almost two-fold at 24 h.
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Cell Line:bovine chromaffin cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Significantly reduced the cleavage/activation of caspase 3 and the number of Annexin V-positive apoptotic cells induced by rotenone/oligomycin.
Chemical Information
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CAS No. 166374-43-2
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Appearance Solid
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Molecular Weight 281.61
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Formula C11H15Cl3N2
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Color White to off-white
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SMILES
ClC1=NC=C([C@@H]2[C@]3([H])N[C@](CC3)([H])C2)C=C1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (277 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Epibatidine dihydrochloride Related Classifications
HY-118325 Related Classifications
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Keywords
- Epibatidine
- 166374-43-2
- nAChR
- Reactive Oxygen Species (ROS)
- Apoptosis
- PKC
- ERK
- Heme Oxygenase (HO)
- Caspase
- adrenal chromaffin cells
- apoptotic cell death
- cytoprotection
- extracellular regulated kinase
- heme oxygenase-1
- ligand-gated channel activation
- mitochondrial depolarization
- neuronal nicotinic acetylcholine receptor
- protein kinase C
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit