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Cat. No.: HY-N20699

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Geministatin C

Geministatin C is a depside analog derived from Geministatin A (HY-N20700) that exhibits mammalian cytotoxicity against cancer cells and fibroblasts. Geministatin C shows no significant antibacterial activity against Gram-positive bacteria and no antifungal activity against yeast.

For research use only. We do not sell to patients.

CAS No.: 3131756-59-4
Formula: C₃₁H₄₈O₉
Molecular Weight:564.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Geministatin C Chemical Structure

CAS No.: 3131756-59-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Anti-cancerBacterial InfectionFungal Infection

Anti-cancer

Geministatin C exhibits cytotoxicity against mouse myeloma NS-1 cells with an IC₅₀ of 17 μM and against neonatal foreskin fibroblast (NFF) cells with an IC₅₀ of 19 μM^[1].

Bacterial Infection

Geministatin C exhibits no significant antibacterial activity against Bacillus subtilis, Staphylococcus aureus, or methicillin-resistant S. aureus, with MIC values > 100 μg/mL for all three bacterial strains^[1].

Fungal Infection

Geministatin C exhibits no significant antifungal activity against Saccharomyces cerevisiae, with an MIC value > 200 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3131756-59-4
Molecular Weight 564.71
Formula C₃₁H₄₈O₉
SMILES

CCCCC/C=C\C/C=C\CCCCCCCC(C=C1O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)=C(C(O)=C1)C(OC)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganism
Austroacremonium gemini
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Crombie A, et al. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini. The Journal of antibiotics. 2024 Oct;77(10):639-646. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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