CACUL1 - CDK2 associated cullin domain 1 Gene

Also Known as CAC1; C10orf46

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 143384

Summary

Enables protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in testis (RPKM 11.0), bone marrow (RPKM 9.1) and 25 other tissues.

CACUL1 Products (1)

mRNA Protein Name
NM_153810.5 NP_722517.3 CDK2-associated and cullin domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23178685 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19829063 GOA
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19829063 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19829063 GOA
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
19829063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACUL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CACUL1 Q86Y37 ESR1 Homo sapiens P03372
Anti Tag CoIP
23178685
Intra
CACUL1 Q86Y37 ESR1 Homo sapiens P03372
IF
23178685
Cross: Cross-species interaction Intra: Intraspecies interaction