ANAPC13 - anaphase promoting complex subunit 13 Gene

Also Known as SWM1; APC13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25847

Summary

This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein Ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin Ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Ubiquitous expression in thyroid (RPKM 36.9), kidney (RPKM 32.9) and 25 other tissues.

ANAPC13 Products (3)

mRNA Protein Name
NM_001242374.1 NP_001229303.1 anaphase-promoting complex subunit 13
NM_001242375.1 NP_001229304.1 anaphase-promoting complex subunit 13
NM_015391.4 NP_056206.1 anaphase-promoting complex subunit 13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20360068 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
16364912 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANAPC13 Q9BS18 CDC23 Homo sapiens Q9UJX2
TAP
20360068
Intra
ANAPC13 Q9BS18 CDC23 Homo sapiens Q9UJX2
Anti Tag CoIP
33961781
Intra
ANAPC13 Q9BS18 CDC23 Homo sapiens Q9UJX2
Anti Tag CoIP
28514442
Intra
ANAPC13 Q9BS18 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra
ANAPC13 Q9BS18 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ANAPC13 Q9BS18 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ANAPC13 Q9BS18 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00677 ANAPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00678 ANAPC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00679 ANAPC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21090 Anapc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27608 Anapc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown