RWDD3 - RWD domain containing 3 Gene

Also Known as RSUME

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25950

Summary

Involved in positive regulation of hypoxia-inducible factor-1alpha signaling pathway and positive regulation of protein sumoylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in prostate (RPKM 8.1), endometrium (RPKM 7.8) and 25 other tissues.

RWDD3 Products (5)

mRNA Protein Name
NM_001128142.2 NP_001121614.2 RWD domain-containing protein 3 isoform b
NM_001199682.2 NP_001186611.2 RWD domain-containing protein 3 isoform c
NM_001278247.2 NP_001265176.2 RWD domain-containing protein 3 isoform d
NM_001278248.2 NP_001265177.2 RWD domain-containing protein 3 isoform e
NM_015485.5 NP_056300.3 RWD domain-containing protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17956732 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
23469069 GOA
involved in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IDA
IDA: Inferred from direct assay
23469069 GOA
involved in positive regulation of protein sumoylation IDA
IDA: Inferred from direct assay
23469069 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RWDD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RWDD3 Q9Y3V2 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17956732
Intra
RWDD3 Q9Y3V2 UBE2I Homo sapiens P63279
Confocal
17956732
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12356 RWDD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16426 RWDD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28266 Rwdd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown