PRPSAP2 - phosphoribosyl pyrophosphate synthetase associated protein 2 Gene
Also Known as PAP41
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 5636
Summary
This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Ubiquitous expression in lymph node (RPKM 12.0), testis (RPKM 9.5) and 25 other tissues.
PRPSAP2 Products (17)
| mRNA | Protein | Name |
|---|---|---|
| NM_001243936.2 | NP_001230865.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 2 |
| NM_001243940.1 | NP_001230869.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 3 |
| NM_001243941.1 | NP_001230870.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 |
| NM_001243942.1 | NP_001230871.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 |
| NM_001353096.1 | NP_001340025.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 5 |
| NM_001353097.2 | NP_001340026.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 5 |
| NM_001353098.2 | NP_001340027.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 6 |
| NM_001353099.2 | NP_001340028.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 5 |
| NM_001353100.2 | NP_001340029.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 |
| NM_001353101.2 | NP_001340030.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| NM_001353102.2 | NP_001340031.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| NM_001353103.2 | NP_001340032.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 |
| NM_001353104.2 | NP_001340033.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 4 |
| NM_001353105.2 | NP_001340034.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| NM_001353106.2 | NP_001340035.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| NM_001353107.2 | NP_001340036.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| NM_002767.4 | NP_002758.1 | phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
26496610 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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PRPSAP2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PRPSAP2 | O60256 | TEX11 | Homo sapiens | Q8IYF3-3 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | TEX11 | Homo sapiens | Q8IYF3-3 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | TEX11 | Homo sapiens | Q8IYF3-3 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS2 | Homo sapiens | P11908-2 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS2 | Homo sapiens | P11908-2 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS2 | Homo sapiens | P11908-2 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP1 | Homo sapiens | Q14558 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP1 | Homo sapiens | Q14558 | 33961781 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP1 | Homo sapiens | Q14558 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP1 | Homo sapiens | Q14558 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS1 | Homo sapiens | P60891 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP2 | Homo sapiens | O60256 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP2 | Homo sapiens | O60256 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPSAP2 | Homo sapiens | O60256 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS1 | Homo sapiens | P60891 | 32296183 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS1 | Homo sapiens | P60891 | 33961781 | |
|
Intra
|
PRPSAP2 | O60256 | PRPS1 | Homo sapiens | P60891 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction