INTS12 - integrator complex subunit 12 Gene

Also Known as INT12; PHF22; SBBI22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57117

Summary

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in thyroid (RPKM 6.3), bone marrow (RPKM 5.9) and 25 other tissues.

INTS12 Products (2)

mRNA Protein Name
NM_001142471.2 NP_001135943.1 integrator complex subunit 12
NM_020395.4 NP_065128.2 integrator complex subunit 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
Biological Process GO Annotation Evidence References Source
involved in snRNA processing IDA
IDA: Inferred from direct assay
16239144 GOA
Cellular Component GO Annotation Evidence References Source
part of integrator complex IDA
IDA: Inferred from direct assay
16239144 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23904267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INTS12 Q96CB8 HAPSTR1 Homo sapiens Q14CZ0
Y2H Array
32296183
Intra
INTS12 Q96CB8 HAPSTR1 Homo sapiens Q14CZ0
Y2H Prey Pooling
32296183
Intra
INTS12 Q96CB8 GTF2IRD1 Homo sapiens Q9UHL9
Y2H
26275350
Intra
INTS12 Q96CB8 INTS1 Homo sapiens Q8N201
Anti Tag CoIP
33961781
Intra
INTS12 Q96CB8 INTS1 Homo sapiens Q8N201
Anti Tag CoIP
28514442
Intra
INTS12 Q96CB8 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra
INTS12 Q96CB8 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06850 INTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06851 INTS10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06852 INTS11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06853 INTS14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06854 INTS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown