PAAF1 - proteasomal ATPase associated factor 1 Gene

Also Known as PAAF; Rpn14; WDR71

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80227

Summary

This gene encodes a WD repeat-containing protein involved in regulation of association of Proteasome components. During HIV Infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Ubiquitous expression in brain (RPKM 8.9), testis (RPKM 8.5) and 25 other tissues.

PAAF1 Products (6)

mRNA Protein Name
NM_001267803.2 NP_001254732.1 proteasomal ATPase-associated factor 1 isoform 1
NM_001267804.2 NP_001254733.1 proteasomal ATPase-associated factor 1 isoform 1
NM_001267805.2 NP_001254734.1 proteasomal ATPase-associated factor 1 isoform 1
NM_001267806.2 NP_001254735.1 proteasomal ATPase-associated factor 1 isoform 3
NM_001363556.2 NP_001350485.1 proteasomal ATPase-associated factor 1 isoform 4
NM_025155.3 NP_079431.1 proteasomal ATPase-associated factor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19490896 GOA
Cellular Component GO Annotation Evidence References Source
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAAF1 Q9BRP4 PSMC5 Homo sapiens P62195
Anti Tag CoIP
19490896
Intra
PAAF1 Q9BRP4 PSMC5 Homo sapiens P62195
Anti Bait CoIP
17353931
Cross: Cross-species interaction Intra: Intraspecies interaction