SPSB4 - splA/ryanodine receptor domain and SOCS box containing 4 Gene

Also Known as SSB4; SSB-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92369

Summary

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of protein polyubiquitination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Low expression observed in reference dataset.

SPSB4 Products (1)

mRNA Protein Name
NM_080862.3 NP_543138.1 SPRY domain-containing SOCS box protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15601820 GOA
enables ubiquitin-like ligase-substrate adaptor activity IPI
IPI: Inferred from physical interaction
21199876 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein polyubiquitination IDA
IDA: Inferred from direct assay
28931592 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
21199876 GOA
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
26392558 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
21199876 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26392558 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21199876 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPSB4 Q96A44 ELOC Homo sapiens Q15369
Anti Tag CoIP
19159283
Intra
SPSB4 Q96A44 ELOC Homo sapiens Q15369
Anti Tag CoIP
33961781
Intra
SPSB4 Q96A44 ELOC Homo sapiens Q15369
Anti Tag CoIP
15601820
Intra
SPSB4 Q96A44 PAWR Homo sapiens Q96IZ0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction