Glucoerucin potassium
Based on 1 Customer Validation
Glucoerucin potassium is an orally active PTP1B non-competitive allosteric inhibitor (IC50 = 6.07 μM) and H2S donor that can be isolated and extracted from Eruca sativa. Glucoerucin potassium upregulates the Nrf2 pathway and promotes irisin/UCP1-mediated adipose tissue browning through conversion to erucin or acting as a sustained-release H2S donor, thereby regulating metabolic and cardiovascular functions. Glucoerucin potassium also exerts anticancer effects by upregulating epoxide hydrolase and through non-competitive allosteric inhibition of PTP1B. Glucoerucin potassium can be used in research on obesity, cancer, type 2 diabetes, and cardiovascular and cerebrovascular diseases.
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 15592-37-7
- Formula: C12H22KNO9S3
- Molecular Weight:459.60
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Glucoerucin (0.1-500 µM; 6 days) potassium shows almost no inhibitory activity against the proliferation of human erythroleukemia K562 cells[4].
Glucoerucin (1.5 g; 37 °C) potassium is completely hydrolyzed by myrosinase from Sinapis alba to give erucin in 82% yield[8].
Glucoerucin (1 mM; 6 h) potassium is oxidized by a 4-fold excess of H2O2 in water at room temperature to glucoraphanin with a conversion rate of 97%[8].
Glucoerucin (0.1-200 µM; 30 min) potassium inhibits recombinant human PTP1B non-competitively in a cell-free pNPP assay, with an IC50 of 6.07 µM and a Ki of 6.29 µM[9].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:cells from rat lung sections
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Concentration:1, 2.5, 10, 25 µM
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Incubation Time:24 h
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Result:Significantly upregulated the protein expression of CYP1A1 and CYP1B1.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (high-fat diet (HFD)-induced mouse obesity model)[6]
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Dosage:10 mg/kg
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Administration:p.o.; once daily; 10 weeks
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Result:Improved glycemic and lipid metabolism, and significantly reduced triglycerides.
Decreased the deposition of visceral white adipose tissue (vWAT) and the volume of white adipocytes.
Alleviated inflammation (reduced IL-6) and oxidative stress (restored Nrf2 levels) in vWAT.
Increased the expression of PGC-1α and FNDC5 in skeletal muscle, elevated blood irisin levels, and up-regulated UCP1 expression in vWAT, promoting browning and thermogenesis.
Chemical Information
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CAS No. 15592-37-7
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Appearance Solid
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Molecular Weight 459.60
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Formula C12H22KNO9S3
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Color White to off-white
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SMILES
CSCCCC/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 11.49 mg/mL (25.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (294 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1758 mL | 10.8790 mL | 21.7581 mL | 54.3951 mL |
| 5 mM | 0.4352 mL | 2.1758 mL | 4.3516 mL | 10.8790 mL | |
| 10 mM | 0.2176 mL | 1.0879 mL | 2.1758 mL | 5.4395 mL | |
| 15 mM | 0.1451 mL | 0.7253 mL | 1.4505 mL | 3.6263 mL | |
| 20 mM | 0.1088 mL | 0.5440 mL | 1.0879 mL | 2.7198 mL |
Glucoerucin potassium Related Classifications
HY-N8445 Related Classifications
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