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Cat. No.: HY-190203

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GSPT1 degrader-20

GSPT1 degrader-20 is a cereblon (CRBN)-recruiting molecular glue degrader (with a
DC₅₀ < 1 nM against GSPT1 HiBiT) that promotes the ubiquitination and proteasomal degradation of GSPT1 and/or IKZF1. GSPT1 degrader-20 can be used in research on hematological malignancies such as acute lymphoblastic leukemia.

For research use only. We do not sell to patients.

CAS No.: 2930694-64-5
Formula: C₂₃H₂₃N₃O₄
Molecular Weight:405.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSPT1 degrader-20 Chemical Structure

CAS No.: 2930694-64-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Eukaryotic Release Factor (eRF) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MHH-CALL-4	EC50	< 0.001 μM	Exerts an anti-proliferative effect on MHH-CALL-4 (B-ALL) cells. Exerts an anti-proliferative effect on MHH-CALL-4 (B-ALL) cells.	en?oq=WO2023096822+A1

In Vitro

Anti-cancerOthers

Anti-cancer

GSPT1 degrader-20 (72 h) has an EC₅₀ of < 0.001 μM against MHH-CALL-4 (B-ALL) cell proliferation^[1].

Others

GSPT1 degrader-20 (compound 11) (4 h) induces GSPT1 degradation in HEK293-hGSPT1-HiBiT cells with a HiBiT DC₅₀ of < 0.001 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2930694-64-5
Molecular Weight 405.45
Formula C₂₃H₂₃N₃O₄
SMILES

O=C(N1)CCC(N2CC3=C(C=CC(CC(NCCC4=CC=CC=C4)=O)=C3)C2=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishiguchi G A, et al. Substituted 2-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide analogs as modulators of gspt1 and/or ikzf1 protein. WO2023096822A1. WIPO. 2023‑06‑01.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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