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Cat. No.: HY-190175

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GSPT1 degrader-28

GSPT1 degrader-28 is a GSPT1 molecular glue degrader with an EC₅₀ of 0.170 μM. GSPT1 degrader-28 induces ubiquitination and proteasomal degradation of GSPT1 and SALL4 by recruiting the CRBN E3 ubiquitin ligase complex. GSPT1 degrader-28 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2631059-91-9
Formula: C₂₃H₂₅N₅O₂
Molecular Weight:403.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSPT1 degrader-28 Chemical Structure

CAS No.: 2631059-91-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

eRF3a/GSPT1

0.170 μM (EC₅₀)

All Eukaryotic Release Factor (eRF) Isoforms :

In Vitro

Cell Cycle Regulation

GSPT1 degrader-28 (Compound I-10) (10 μM; 24 h) concentration-dependently degrades G1 to S phase transition protein 1 (GSPT1) in GripTite^TM 293 MSR cells, reducing protein levels by 80%^[1].
GSPT1 degrader-28 (10 μM; 24 h) degrades Spalt-like transcription factor 4 (SALL4) in GripTiteTM 293 MSR cells, reducing protein levels by 60%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2631059-91-9
Molecular Weight 403.48
Formula C₂₃H₂₅N₅O₂
SMILES

O=C(NC1=O)CCN1C2=CN=C(C=C3)N2C=C3C4CCN(CC5=CC=CC=C5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Axford J, et al. Glue degraders and methods of use thereof. WO2021053555A1, 2021.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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GSPT1 degrader-28

All Eukaryotic Release Factor (eRF) Isoforms