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Cat. No.: HY-190277

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H-APPAMP-023

H-APPAMP-023 is a molecular glue. H-APPAMP-023 inhibits CDK activity, with IC₅₀ values of 102 nM and 702 nM for CDK7 and CDK12, respectively.

For research use only. We do not sell to patients.

CAS No.: 2654076-02-3
Formula: C₂₄H₂₉F₃N₈O
Molecular Weight:502.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-APPAMP-023 Chemical Structure

CAS No.: 2654076-02-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

H-APPAMP-023 is a molecular glue. H-APPAMP-023 inhibits CDK activity, with IC₅₀ values of 102 nM and 702 nM for CDK7 and CDK12, respectively^[1].

IC₅₀ & Target

^[1]

CDK7

102 nM (IC₅₀)

CDK12

702 nM (IC₅₀)

All CDK Isoforms :

In Vitro

Cell Cycle Regulation

H-APPAMP-023 inhibits the enzymatic activity of CDK7 in a cell-free system with an IC₅₀ of 102 nM, and shows weak inhibitory activity against CDK12 with an IC₅₀ of 702 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2654076-02-3
Molecular Weight 502.54
Formula C₂₄H₂₉F₃N₈O
SMILES

CC(C1=C2N=C(NC[C@H]3CCNC[C@@H]3O)C=C(NCC4=C(C(F)(F)F)N5C=CC=CC5=N4)N2N=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ainscow E, et al; Carrick Therapeutics Limited. Cyclin K degraders. WO 2021/122745 A1. Published 2021 Jun 24.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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H-APPAMP-023

All CDK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

H-APPAMP-023 Related Classifications

HY-190277 Related Classifications

Bioz

Keywords

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