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Cat. No.: HY-187394

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hIgG-hFc receptor-IN-3

hIgG-hFc receptor-IN-3 is a protein-protein interaction inhibitor of human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn). Identified via virtual ligand screening and optimized through structure-activity relationship studies, hIgG-hFc receptor-IN-3 competitively inhibits the binding of IgG to FcRn, thereby accelerating the clearance of endogenous IgG. hIgG-hFc receptor-IN-3 can be used for the research of autoimmune diseases.

For research use only. We do not sell to patients.

CAS No.: 1425050-80-1
Formula: C₂₅H₂₇N₅O₂
Molecular Weight:429.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

hIgG-hFc receptor-IN-3 Chemical Structure

CAS No.: 1425050-80-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

hIgG-hFc receptor-IN-3 is a quinoxaline-based small molecule, which is a novel FcRn antagonist obtained through structure-activity relationship (SAR) optimization of hit compounds identified via virtual ligand screening^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 1425050-80-1
Molecular Weight 429.51
Formula C₂₅H₂₇N₅O₂
SMILES

N#CC(C1=NC2=C(N=C1N3CCCCCC3)C=CC=C2)C(NCC4=CC(OC)=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction. Bioorganic & medicinal chemistry letters. 2013 Mar 01;23(5):1253-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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