KAT6A/B-IN-1
KAT6A/B-IN-1 is a KAT6A/KAT6B inhibitor (IC50 = 3.2 nM and 25.2 nM) that inhibits lysine acetyltransferase activity. KAT6A/B-IN-1 inhibits cancer cell proliferation and tumor growth in xenograft models. KAT6A/B-IN-1 exhibits chemical and physical stability, low hygroscopicity, and reduced sensitivity to heat, humidity, and light. KAT6A/B-IN-1 is used in the study of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3068205-08-0
- Formula: C22H22N4O7S
- Molecular Weight:486.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
KAT6A 3.2 nM (IC50) |
KAT6B 25.2 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ZR-75-1 | IC50 |
3.2 nM
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Inhibition of proliferation of human ZR-75-1 breast cancer cells incubated for 10 days with compound re-added every 5 days, measured by luminescence using CellTiter-Glo reagent.
Inhibition of proliferation of human ZR-75-1 breast cancer cells incubated for 10 days with compound re-added every 5 days, measured by luminescence using CellTiter-Glo reagent.
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In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ZR-75-1 xenograft model in BALB/c nude mice (female, 6–8 weeks)[1]
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Dosage:0.3 mg/kg
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Administration:subcutaneous injection; 21 days
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Result:Showed significant antitumor activity in the ZR-75-1 xenograft model, with a TGI of 93.97% on day 21 after administration.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- Patient-Derived Orthotopic Xenograft (PDOX)
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Patient-Derived Xenograft (PDX)
- Splenic/Portal-Vein Liver Metastasis Xenograft
- MTT Cell Proliferation Assay
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Intraperitoneal/Peritoneal Dissemination Xenograft
Chemical Information
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CAS No. 3068205-08-0
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Molecular Weight 486.50
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Formula C22H22N4O7S
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SMILES
COC1=CC=C(OCCCO2)C2=C1S(NC3=NOC4=CC(CN5N=CC=C5)=CC(OC)=C34)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KAT6A/B-IN-1 Related Classifications
HY-187466 Related Classifications
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