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Cat. No.: HY-189669

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KP-S54

KP-S54 is an antiviral agent derived from GS-441524 (HY-103586) and also a SARS-CoV-2 Mac1 and MERS-CoV Mac1 inhibitor. KP-S54 blocks interferon-induced reversal of ADP-ribosylation, with an IC₅₀ value of 44 nM against SARS-CoV-2 and an IC₅₀ value of 91 nM against MERS-CoV. KP-S54 produced no detectable antiviral efficacy in a SARS-CoV-2-infected mouse model. KP-S54 can be used for research related to SARS-CoV and MERS-CoV infection.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₁N₉O₇S
Molecular Weight:661.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KP-S54 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

KP-S54 (compound 18c) exhibits inhibitory activity against recombinant SARS-CoV-2 Mac1 (IC₅₀ = 44 nM) and MERS-CoV Mac1 (IC₅₀ = 91 nM)^[1].
KP-S54 (1 μM) exhibited half-lives of 17, 41, and 35 min in mouse, rat, and human liver microsomes, respectively, with 32.8% remaining in mouse MLM after 15 min^[1].
KP-S54 (500 μM; 5 h) exhibited a PAMPA permeability of approximately 4.72 × 10^-6 cm/s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Viral Infection

KP‑S54 (compound 18c) (100 mg/kg; intraperitoneal injection, once daily, from 1 day before infection to day 6 after infection) produced no detectable antiviral efficacy in a SARS‑CoV‑2-infected mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 661.69
Formula C₃₀H₃₁N₉O₇S
SMILES

CN(C(CNC(C1=CN=CC(NS(=O)(C2=CC=CC=C2)=O)=C1)=O)=O)C[C@H]3O[C@@](C4=CC=C5C(N)=NC=NN54)([C@@H]6OC(C)(O[C@H]36)C)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Peng K, et al. Development of GS-441524 derivatives as potent SARS-CoV-2 Mac1 inhibitors via a direct-to-biology approach. European journal of medicinal chemistry. 2026 Sep 10;320:119280.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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