Metamizole magnesium
Metamizole (Dipyrone; Methamizole) magnesium is an orally active cyclooxygenase (COX) and G6PD inhibitor. Metamizole magnesium is a potent analgesic and antipyretic agent. Metamizole magnesium inhibits cell proliferation and promotes apoptosis. Metamizole magnesium has anti-inflammatory and antioxidant activities. Metamizole sodium can be used for research on fever and various types of pain.
For research use only. We do not sell to patients.
- CAS No.: 63372-86-1
- Formula: C26H32MgN6O8S2
- Molecular Weight:645.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, adult, 200-250 g)[1]
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Dosage:200 mg/kg
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Administration:i.p.; single dose; 1.5, 6, 12 h
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Result:Inhibited the glucose 6-phosphate dehydrogenase (G6PD) activity by 40% during the first 1.5 h.
Did not show an inhibitory effect in the following time periods (6 and 12 h).
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Research Protocol for Inflammation-related Diseases
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Apoptosis Solutions
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 63372-86-1
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Molecular Weight 645.00
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Formula C26H32MgN6O8S2
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SMILES
C[N](C1)(C2=C(C)N(C)N(C3=CC=CC=C3)C2=O)[Mg+2]([O-]4)([O-]S1(=O)=O)[N](CS4(=O)=O)(C5=C(C)N(C)N(C6=CC=CC=C6)C5=O)C
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Synonyms
Dipyrone magnesium; Methamizole magnesium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ciftçi M, et al. Effects of metamizol and magnesium sulfate on enzyme activity of glucose 6-phosphate dehydrogenase from human erythrocyte in vitro and rat erythrocyte in vivo. Clinical biochemistry. 2001 Jun;34(4):297-302. [Content Brief]
[2]. Gozzoli V, et al. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive care medicine. 2004 Mar;30(3):401-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Metamizole magnesium Related Classifications
HY-107796 Related Classifications
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