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Mibavademab

(Synonyms: REGN4461)
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Based on 1 Customer Validation

Mibavademab (REGN4461) is a LEPR agonist monoclonal antibody. Mibavademab activates leptin receptor (leptin receptor) and LEPR signaling, enhances leptin (leptin)-induced STAT3 activity without competing with leptin binding, and binds with high affinity to the human LEPR extracellular domain. Mibavademab can be used for research on leptin deficiency.

For research use only. We do not sell to patients.

  • Purity : ≥99.0%
  • CAS No.: 2305770-44-7
  • Molecular Weight:145.58 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Mibavademab
  • Experimental Validation Results for Mibavademab
  • Experimental Validation Results for Mibavademab
  • Mibavademab Chemical Structure
    Mibavademab Chemical Structure
CAS No.: 2305770-44-7
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Mibavademab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Leptin R/LEPR Protein, Human (HEK293, His, HY-P72524) can bind Mibavademab. The EC50 for this effect is 12.50 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 K562 cells with Mibavademab (HY-P990631, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Mibavademab Chemical Structure
    1/16
  • Mibavademab
  • Immobilized Leptin R/LEPR Protein, Human (HEK293, His, HY-P72524) can bind Mibavademab. The EC50 for this effect is 12.50 ng/mL.
  • Flow cytometric analysis of 1X106 K562 cells with Mibavademab (HY-P990631, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).