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Cat. No.: HY-187583

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MOA-stilbene

MOA-stilbene is an inhibitor targeting mitochondrial complex III, with fungicidal and insecticidal activities. MOA-stilbene binds to the Qo center of cytochrome b (i.e., the ubiquinol oxidation site, center o), blocking electron transport and inhibiting mitochondrial cellular respiration, thereby reducing the production of reactive oxygen species. MOA-stilbene binds to the Qi center of the chloroplast b6f-complex, inhibiting the reoxidation of reduced bH and bL hemes, the reverse electron transfer from cytochrome c + c1 and ISP to bH and bL, and the electron transfer from bH to bL.

For research use only. We do not sell to patients.

CAS No.: 103455-29-4
Formula: C₁₉H₁₈O₃
Molecular Weight:294.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MOA-stilbene Chemical Structure

CAS No.: 103455-29-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Oxidative StressBacterial InfectionMitochondrial FunctionMitochondrial Oxidative Phosphorylation

Oxidative Stress

In COS-7 cells and SMP, MOA-stilbene (1 μM; 1 h) produces hydrogen peroxide levels similar to control values under basal conditions; however, in glucose-supplemented COS-7 cells, MOA-stilbene substantially decreases the rate and extent of hydrogen peroxide production, especially in the presence of C6-ceramide^[1].

Bacterial Infection

MOA-stilbene is a potent inhibitor of mitochondrial respiration in bovine heart mitochondria, exhibiting an I₅₀ of 0.04 mM^[2].
In bovine SMP, MOA-stilbene (5 mM) in combination with antimycin causes less inhibition of succinate-induced b heme reduction than the combination of antimycin and myxothiazol^[3].

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

MOA-stilbene inhibits complex III from yeast, Botrytis, fly, rat, and corn with pI₅₀ values of 7.3, 7.4, 7.8, 7.6, and 6.3, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

ROS/oxidative-stress fluorescent staining

Chemical Information

CAS No. 103455-29-4
Molecular Weight 294.34
Formula C₁₉H₁₈O₃
SMILES

COC(/C(C1=C(C=CC=C1)/C=C/C2=CC=CC=C2)=C/OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Degli Esposti M, et al. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis. FEBS letters. 1998 Jul 03;430(3):338-42.

[2]. Zakharychev V V, Kovalenko L V. Natural compounds of the strobilurin series and their synthetic analogues as cell respiration inhibitors[J]. Russian chemical reviews, 1998, 67(6): 535-544.

[3]. Matsuno-Yagi A, Hatefi Y. Ubiquinol-Cytochrome c Oxidoreductase: THE REDOX REACTIONS OF THE BIS-HEME CYTOCHROME b IN UBIQUINONE-SUFFICIENT AND UBIQUINONE-DEFICIENT SYSTEMS (∗)[J]. Journal of Biological Chemistry, 1996, 271(11): 6164-6171.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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