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Cat. No.: HY-N22074

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Monocillin IV

Monocillin IV is a macrolide with antibacterial and anti-HIV-1 activities, originally isolated and identified from the metabolites of Monocillium nordinii. Monocillin IV is an inhibitor of HIV-1 Tat protein transactivation, with an IC₅₀ of 5.0 µM. Monocillin IV inhibits HIV-1 viral replication by blocking the Tat transactivation pathway. Monocillin IV exhibits moderate antibacterial activity, with an MIC of 25.6 µg/mL against Xanthomonas campestris pv. campestris . Monocillin IV can be used for research on black rot and HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 75207-14-6
Formula: C₁₈H₂₂O₅
Molecular Weight:318.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Monocillin IV Chemical Structure

CAS No.: 75207-14-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

HIV-1

All Endogenous Metabolite Isoforms :

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	5.0 μM	Inhibition of HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells harboring integrated HIV-1 provirus luciferase reporter incubated 24 hrs by luciferase assay. Inhibition of HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells harboring integrated HIV-1 provirus luciferase reporter incubated 24 hrs by luciferase assay.	17191924
Jurkat	IC₅₀	>100 μM	Cytotoxicity against human Jurkat cells assessed as viability reduction by MTS assay. Cytotoxicity against human Jurkat cells assessed as viability reduction by MTS assay.	17191924
HeLa	IC₅₀	6.2 μM	Antiviral activity against HIV H9IIIb in P4/P5 HeLa cells containing integrated LTR-LacZ reporter assessed by β-gal substrate after 48 hrs incubation. Antiviral activity against HIV H9IIIb in P4/P5 HeLa cells containing integrated LTR-LacZ reporter assessed by β-gal substrate after 48 hrs incubation.	17191924

In Vitro

Bacterial InfectionParasitic InfectionViral Infection

Bacterial Infection

Monocillin IV (0.4-204.8 µg/mL; 24 h) inhibits the growth of Xanthomonas campestris pv. campestris, with an MIC of 25.6 µg/mL^[1].

Parasitic Infection

Monocillin IV (1.25-10 mg/mL; 24 h) shows no activity against Meloidogyne incognita J2s and exhibited no nematicidal effect above 1,000 μg/mL^[2].

Viral Infection

Monocillin IV (up to 100 μM; 24 h) inhibits HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells with an IC₅₀ of 5 µM^[4].
Monocillin IV (up to 100 μM) exhibits no significant cytotoxicity in the Jurkat-derived cell line (63A9) (IC₅₀ >100 µM)^[4].
Monocillin IV (48 h) exhibits antiviral activity against single-cycle HIV viral replication in P4/P5 Hela cells expressing CD4 and CCR5, with an IC₅₀ of 6.2 µM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Xanthomonas campestris pv. campestris
Concentration:

Two-fold serial dilution concentration gradient from 204.8 µg/mL to 0.4 µg/mL
Incubation Time:

24 h
Result:

Exhibited modest inhibitory effects against Xanthomonas campestris, with MIC of 25.6 µg/mL.

Related Protocols :

Chemical Information

CAS No. 75207-14-6
Molecular Weight 318.36
Formula C₁₈H₂₂O₅
SMILES

OC1=C2C(CC(CCCC/C=C/C[C@H](OC2=O)C)=O)=CC(O)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Monocillium nordinii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qin F, et al. Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster. J Agric Food Chem. 2019;67(26):7266-7273.

[2]. Li Z, et al. Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes. Front Microbiol. 2024;15:1385255.

[3]. Gao J, et al. Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors. Journal of natural products. 2013 May 24;76(5):824-8. [Content Brief]

[4]. Jayasuriya H, et al. Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation. Chemistry & biodiversity. 2005 Jan;2(1):112-22.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Monocillin IV

All Endogenous Metabolite Isoforms

All HIV Isoforms