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Cat. No.: HY-B0615AS

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Moricizine-d₈ Hydrochloride

Name: Moricizine-d8 Hydrochloride
Brand: MedChemExpress
SKU: HY-B0615AS
Price: 995.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: EN 313-d₈; Ethmozin-d₈; Moracizine-d₈)

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Moricizine-d₈ Hydrochloride (EN 313-d₈; Ethmozin-d₈; Moracizine-d₈) is the deuterated-labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride (EN 313) is an orally active cardiac sodium channel blocker. Moricizine Hydrochloride blocks inactivated sodium channels in a slow dissociation manner, inhibiting late and peak sodium currents, p-CaMKII, atrial enlargement, and cardiac hypertrophy. Moricizine Hydrochloride can be used in research on atrial fibrillation and arrhythmias.

For research use only. We do not sell to patients.

Purity : 99.61%
CAS No.: 2300178-76-9
Formula: C₂₂H₁₈D₈ClN₃O₄S
Molecular Weight:472.03

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Moricizine-d₈ Hydrochloride Chemical Structure

CAS No.: 2300178-76-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
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Chemical Information
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Biological Activity

Description

All Sodium Channel Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2300178-76-9
Unlabeled CAS 29560-58-5
Appearance Solid
Molecular Weight 472.03
Formula C₂₂H₁₈D₈ClN₃O₄S
Color Off-white to pink
SMILES

[2H]C1([2H])C([2H])([2H])OC([2H])([2H])C([2H])([2H])N1CCC(N2C3=CC(NC(OCC)=O)=CC=C3SC4=CC=CC=C42)=O.Cl
Synonyms

EN 313-d₈; Ethmozin-d₈; Moracizine-d₈
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zou T, et al. Moricizine prevents atrial fibrillation by late sodium current inhibition in atrial myocytes. Journal of thoracic disease. 2022 Jun;14(6):2187-2200.

[2]. Han C, et al. Clock-Modulating Activities of the Anti-Arrhythmic Drug Moricizine. Clocks & sleep. 2021 Jun 22;3(3):351-365.

[3]. Konishi H, et al. Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A. Pharmacology. 2002 Dec;66(4):190-8.

[4]. Abalakov GA, et al. Moricizine (ethmozine) can break electrical coupling between rat right atrial working cardiomyocytes in vitro. Bulletin of Experimental Biology and Medicine. 2018 Jul;165(3):351-5.

[5]. Ahmmed GU, et al. Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Vascular pharmacology. 2002 Mar;38(3):131-41. [Content Brief]

[6]. Saeki T, et al. Block of Na+ channel by moricizine hydrochloride in isolated feline ventricular myocytes. European journal of pharmacology. 1994 Aug 22;261(3):249-56.

[7]. Maruyama K, et al. Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells. British journal of pharmacology. 1995 Jan;114(1):19-26.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Moricizine-d₈ Hydrochloride

All Sodium Channel Isoforms

Biological Activity

Description

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

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Moricizine-d8 Hydrochloride

All Sodium Channel Isoforms

Biological Activity

Description

Application

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Help & FAQs

Moricizine-d8 Hydrochloride Related Classifications

HY-B0615AS Related Classifications

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Moricizine-d₈ Hydrochloride

Moricizine-d₈ Hydrochloride Related Classifications