NVS-VHL785
NVS-VHL785 is a VHL-binding molecular glue that selectively degrades CDO1. NVS-VHL785 recruits CDO1 to the VHL-cullin-RING ubiquitin ligase complex, inducing ubiquitin-proteasome-dependent degradation of CDO1. NVS-VHL785 can be used for research related to CDO1-mediated diseases.
For research use only. We do not sell to patients.
- CAS No.: 1448189-67-0
- Formula: C23H30N4O4S
- Molecular Weight:458.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
NVS‑VHL785 induces CDO1‑VHL ternary complex assembly in the TR‑FRET biochemical assay (AC50 =194 nM) and the cellular NanoBiT assay (AC50 =701 nM)[1].
NVS‑VHL785 directly binds the VHL protein, with a binary binding KD =220 nM measured by SPR; the VHL‑compound 7‑CDO1 ternary complex has an SPR KD =0.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1448189-67-0
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Molecular Weight 458.57
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Formula C23H30N4O4S
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SMILES
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NVS-VHL785 Related Classifications
HY-190187 Related Classifications
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