Otlertuzumab
Based on 1 Customer Validation
Otlertuzumab (TRU-016) is a humanized anti-CD37 monoclonal antibody that can be used for cancer research.
For research use only. We do not sell to patients.
- Purity : 99.00%
- CAS No.: 1372645-37-8
- Molecular Weight:104.81 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
[(scFv-heavy-kappa)G1-h-CH2-CH3]2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
TSPAN26/CD37
In Vitro
Otlertuzumab (TRU-016) in combination with Rituximab (HY-P9913), Rapamycin (HY-10219), or Bendamustine (HY-13567) increases cell killing of NHL cells[2].
Otlertuzumab has the ability to bind to and kill CD37+ cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Otlertuzumab shows significant antitumor activity in mice bearing Ramos or Daudi tumor xenografts[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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[(scFv-heavy-kappa)G1-h-CH2-CH3]2
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CD37 Protein, Human can bind Otlertuzumab. The EC50 for this effect is 37.2 ng/mL. -
Flow Cytometry analysis of Raji cells labelling TSPAN26/CD37 (red) with Otlertuzumab (anti-TSPAN26/CD37) (HY-P99212). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1372645-37-8
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Appearance Liquid
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Molecular Weight 104.81 kDa
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Color Colorless to light yellow
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SMILES
[Otlertuzumab]
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Synonyms
TRU-016
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)