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Cat. No.: HY-190259

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PDE3A/B-IN-2

PDE3A/B-IN-2 is a PDE3A/B inhibitor that inhibits tumor cell proliferation and modulates the formation of PDE3A-SLFN12 and PDE3B-SLFN12 complexes. PDE3A/B-IN-2 is also a molecular glue. PDE3A/B-IN-2 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2275774-53-1
Formula: C₁₅H₁₃F₃N₄O₂
Molecular Weight:338.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-2 Chemical Structure

CAS No.: 2275774-53-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE3A/B-IN-2 (Example 128) inhibits the enzymatic activity of PDE3A and PDE3B in a cell-free system, with IC50 values of 280 nM and 270 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2275774-53-1
Molecular Weight 338.28
Formula C₁₅H₁₃F₃N₄O₂
SMILES

CC1=C(C2=C(C(F)(F)F)C=C(C3=NNC(OC3)=O)C=C2)C(C)=NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ellermann M, et al. Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Broad Institute Inc, Dana-Farber Cancer Institute Inc. Dihydrooxadiazinones. WO 2019/025562 A1. Published 2019 Feb 07.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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