Peucedanin
Based on 1 Customer Validation
Peucedanin is an orally active insect growth inhibitor and coumarin compound. Peucedanin reduces Hsp27 and Hsp72 expression and blocks Ca2+ channel activity. Peucedanin induces Apoptosis and necrosis. Peucedanin reduces the relative growth rate and consumption rate of Spodoptera littoralis larvae. Peucedanin can be used in research on cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 133-26-6
- Formula: C15H14O4
- Molecular Weight:258.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[2]|
HSP27 |
Hsp72 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa B cells
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Concentration:1, 5, 10, and 15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hoechst 33342 apoptosis was 0.13% at 1 μg/mL (5 h), 0.25% at 5 μg/mL (5 h), 0.20% at 10 μg/mL (5 h), 0.60% at 15 μg/mL (5 h), 0.15% at 5 μg/mL (24 h), 0.20% at 10 μg/mL (24 h), and 1.70% at 15 μg/mL (24 h).
Annexin V apoptosis was 4.65% at 1 μg/mL (5 h), 4.80% at 5 μg/mL (5 h), 3.00% at 10 μg/mL (5 h), 8.35% at 15 μg/mL (5 h), 2.05% at 1 μg/mL (24 h), 4.80% at 5 μg/mL (24 h), 1.90% at 10 μg/mL (24 h), and 11.4% at 15 μg/mL (24 h).
PI necrosis was 0.2% at 1 μg/mL (5 h), 0.5% at 5 μg/mL (5 h), 0.6% at 10 μg/mL (5 h), 0.5% at 15 μg/mL (5 h), 0.30% at 1 μg/mL (24 h), 0.40% at 5 μg/mL (24 h), 0.90% at 10 μg/mL (24 h), and 0.90% at 15 μg/mL (24 h).
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Cell Line:HeLa B cells
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Concentration:15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hsp72 expression was inhibited by 77.5% after 24 h at 15 μg/mL.
Hsp27 was diminished by 74.0% after 5 h at 15 μg/mL compared with control.
In Vivo
Peucedanin (3 μmol/g fresh wt; oral; three days) slightly decreases RGR and RCR in second-instar Spodoptera littoralis larvae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:laboratory colony (neonate larvae)[1]
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Dosage:1.0, 2.0, 3.0, 4.0, and 5.0 μmol/g fresh wt
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Administration:oral; continuous; six days
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Result:At 1, 2, 3, 4, and 5 μmol/g fresh wt, larval growth was 68%, 23%, 22%, 18%, and 8% of control, respectively.
No larvae died during the bioassay.
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Animal Model:laboratory colony (second-instar larvae)[1]
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Dosage:3 μmol/g fresh wt
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Administration:oral; three days
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Result:At 3 μmol/g fresh wt, weight gain was 10.81 mg dry wt, diet consumed was 42.46 mg dry wt, RGR was 0.66 mg/mg/day, and RCR was 2.56 mg/mg/day.
RGR and RCR slightly decreased relative to control.
Chemical Information
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CAS No. 133-26-6
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Molecular Weight 258.27
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Formula C15H14O4
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SMILES
O=C1C=CC2=CC3=C(OC(C(C)C)=C3OC)C=C2O1
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Peucedanin Related Classifications
HY-N7855 Related Classifications
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