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Cat. No.: HY-189661

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RSV-IN-15

RSV-IN-15 is a selective inhibitor of the RSV RNA-dependent RNA polymerase PRNTase domain. RSV-IN-15 blocks polymerase-dependent RNA synthesis through allosteric binding. RSV-IN-15 exhibits antiviral EC₅₀ = 37 nM against the RSV‑A Long strain in Hep‑2 cells, reduces polymerase-dependent reporter gene activity, and inhibits RSV RNA synthesis. RSV-IN-15 can be used for research on respiratory syncytial virus infection.

For research use only. We do not sell to patients.

CAS No.: 3136661-66-7
Formula: C₂₅H₂₅FN₄O₄
Molecular Weight:464.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RSV-IN-15 Chemical Structure

CAS No.: 3136661-66-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	EC50	0.037 μM	Antiviral activity against respiratory syncytial virus A Long strain in HEp-2 cells assessed by cytopathic effect reduction using MTS after 4 days post-infection. Antiviral activity against respiratory syncytial virus A Long strain in HEp-2 cells assessed by cytopathic effect reduction using MTS after 4 days post-infection.	42641470
HEp-2	CC₅₀	>50 μM	Cytotoxicity against HEp-2 cells assessed by MTS after 4 days; CC50 >50 µM; no 50% cytotoxicity reached up to 50 µM. Cytotoxicity against HEp-2 cells assessed by MTS after 4 days; CC50 >50 µM; no 50% cytotoxicity reached up to 50 µM.	42641470

In Vitro

Viral InfectionOthers

Viral Infection

RSV-IN-15 (LX1) (50 µM; 4 days post-infection) inhibits RSV-A Long in HEp-2 cells with an EC₅₀ of 37 nM and a CC₅₀ greater than 50 µM^[1].
RSV-IN-15 reduces RSV polymerase-dependent reporter gene expression and inhibits viral RNA synthesis^[1].

Others

RSV-IN-15 (molecular docking) binds to the allosteric pocket of the RSV polymerase PRNTase and forms stable hydrogen bonds, π-π stacking, and hydrophobic interactions with key amino acid residues of the RSV-L protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 3136661-66-7
Molecular Weight 464.49
Formula C₂₅H₂₅FN₄O₄
SMILES

COC1=C(OC2CC2)C=CC(C(NNC(C3=CC(NCC)=CC(C4=CC=C(F)C=C4)=N3)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li X, et al. Discovery of pyridine formyl hydrazide derivatives as potent non-nucleoside RSV polymerase inhibitors. European journal of medicinal chemistry. 2026 Aug 21;319:119256.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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