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Cat. No.: HY-128736

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L-2-Phosphoglyceric acid

L-2-Phosphoglyceric acid is an endogenous metabolite. L-2-Phosphoglyceric acid serves as a substrate for phosphatases and releases inorganic phosphate upon catalytic dephosphorylation. L-2-phosphoglyceric acid is upregulated in human oral fibroblasts treated with Porphyromonas gingivalis bacterial extracellular vesicles. L-2-Phosphoglyceric acid is useful for research related to prostate cancer and periodontitis.

For research use only. We do not sell to patients.

CAS No.: 23295-92-3
Formula: C₃H₇O₇P
Molecular Weight:186.06

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-2-Phosphoglyceric acid Chemical Structure

CAS No.: 23295-92-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Carbohydrate MetabolismAnti-cancer

Carbohydrate Metabolism

Anti-cancer

L-2-Phosphoglyceric acid levels in PC3 prostate cancer cells decrease upon treatment with a glutaminase inhibitor and increase upon treatment with the hexokinase inhibitor 2-deoxy-D-glucose (HY-13966), reflecting the metabolic crosstalk between glycolysis and glutaminolysis pathways^[2].

Carbohydrate Metabolism

L-2-Phosphoglyceric acid is catalyzed by wild-type Gph and its evolved/single-mutant variants with significant phosphoglycolate phosphatase activity, indicating that the native activity of the enzyme remains largely intact after directed evolution toward phosphoserine phosphatase activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 23295-92-3
Appearance Solid
Molecular Weight 186.06
Formula C₃H₇O₇P
Color White to off-white
SMILES

O=C(O)[C@@H](OP(O)(O)=O)CO
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. SUTHERLAND EW, et al. Mechanism of the phosphoglyceric mutase reaction. J Biol Chem. 1949 Nov;181(1):153-9. [Content Brief]

[2]. Dong XM, et al. Targeted profiling of polar metabolites in cancer metabolic reprogramming by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2022 Dec 20;1686:463654. [Content Brief]

[3]. Yip SH, et al. Substrate ambiguous enzymes within the Escherichia coli proteome offer different evolutionary solutions to the same problem. Molecular biology and evolution. 2013 Sep;30(9):2001-12.

[4]. Haugsten H R, Lipka A, Kristoffersen A K, et al. Metabolic changes in oral fibroblasts after exposure to bacterial extracellular vesicles from three strains of Porphyromonas gingivalis[J]. Cellular Microbiology, 2025, 2025(1): 7515004.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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