25 Results for "

cAMP decrease

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "cAMP decrease" in MCE Product Catalog:

2
PAMP-12 (unmodified)
PAMP-12 (unmodified)
0 Images
2 Cited Publications
Cat. No.: HY-P3419
CAS No.: 929905-12-4
Target:  

Mas-related G-protein-coupled Receptor (MRGPR) PERK Calcium Channel

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

PAMP-12 (unmodified) is an endogenous peptide and is a MrgX2 agonist. PAMP-12 (unmodified) can reduce cAMP accumulation, increase Ca 2+ levels, enhance beta-arrestin recruitment, decrease IP-1, and increases phosphoERK. PAMP-12 (unmodified) can elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP-12 (unmodified) can be used for the research of hypotension and ulcerative colitis .
loading...
    loading...
View All Sizes
1
1-Oleoyl-sn-glycero-3-phosphocholine
1-Oleoyl-sn-glycero-3-phosphocholine
0 Images
1 Cited Publications
Cat. No.: HY-W140439
CAS No.: 19420-56-5
Synonyms: 18:1 Lyso PC
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation .
loading...
    loading...
View All Sizes
1
γ-Glu-Tyr
γ-Glu-Tyr
0 Images
1 Cited Publications
Cat. No.: HY-P4633
CAS No.: 7432-23-7
Target:  

Dipeptidyl Peptidase Endogenous Metabolite CaSR Interleukin Related TNF Receptor PKA NF-κB

Research Areas:  

Metabolic Disease Inflammation/Immunology

γ-Glu-Tyr is an orally active gut microbiota-derived metabolite and a competitive DPP-IV inhibitor with an IC50 of 6.77 mM against hDPP-IV. γ-Glu-Tyr weakly activates hCaSR. γ-Glu-Tyr decreases colonic pro-inflammatory cytokine (IL-6, IL-1β, TNF-α) levels. γ-Glu-Tyr activates the cAMP/PKA signaling pathway and inhibits NF-κB phosphorylation, thereby reducing inflammatory responses. γ-Glu-Tyr can be used for research on type 2 diabetes and ulcerative colitis .
loading...
    loading...
View All Sizes
Aleniglipron
Aleniglipron
0 Images
Cat. No.: HY-160734
CAS No.: 2685823-26-9
Synonyms: GSBR-1290
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease

Aleniglipron (GSBR-1290) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist, with an EC50 value of less than 0.1 nM in HDB cell lines in cAMP stimulation assays. Aleniglipron selectively activates the Gαs-cAMP signaling pathway of GLP-1R without β-arrestin recruitment. Aleniglipron induces insulin release, promotes glucose clearance, reduces food intake and decreases body weight. Aleniglipron is applicable to research related to type 2 diabetes and obesity .
loading...
    loading...
View All Sizes
RTI-122
RTI-122
0 Images
Cat. No.: HY-167856
CAS No.: 3034664-39-3
Target:  

GPR88

Research Areas:  

Neurological Disease

RTI-122 is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC50=11 nM), with EC50 values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([ 35S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 exhibits metabolic stability in mice (T1/2=5.8 h) and can be used to investigate alcohol use disorder .
loading...
    loading...
View All Sizes
3-Hydroxyoctanoic acid
3-Hydroxyoctanoic acid
0 Images
Cat. No.: HY-113058
CAS No.: 14292-27-4
Purity:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Plants Myrtaceae Extract 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.