29

SKF-96365 (hydrochloride)

29 Publications Verification

Cat. No.: HY-100001

CAS No.: 130495-35-1

Purity: ≥99.01%

Target:

TRP Channel CRAC Channel Autophagy CaMK Akt Apoptosis Na+/Ca2+ Exchanger Calcium Channel

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .

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29

SKF-96365

29 Publications Verification

Cat. No.: HY-125942

CAS No.: 162849-90-3

Target:

CRAC Channel TRP Channel CaMK Akt Apoptosis Autophagy Na+/Ca2+ Exchanger Calcium Channel

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .

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14

Allopurinol

14 Cited Publications

Cat. No.: HY-B0219

CAS No.: 315-30-0

Target:

Xanthine Oxidase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

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14

Allopurinol sodium

14 Cited Publications

Cat. No.: HY-B0219A

CAS No.: 17795-21-0

Target:

Xanthine Oxidase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

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11

L-NMMA acetate

11 Cited Publications

Cat. No.: HY-18732A

CAS No.: 53308-83-1

Synonyms: Tilarginine acetate; Methylarginine acetate

Category:

Cardiovascular Disease Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

NO Synthase

L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production . L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia .

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11

L-NMMA

11 Cited Publications

Cat. No.: HY-18732

CAS No.: 17035-90-4

Synonyms: Tilarginine; Methylarginine

Target:

NO Synthase

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

L-NMMA (Tilarginine) is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production . L-NMMA alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA is applicable to research related to nociception, bone cancer pain, and myopia .

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3

A-803467

3 Cited Publications

Cat. No.: HY-11079

CAS No.: 944261-79-4

Purity: 99.09%

Target:

Sodium Channel

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

A-803467 is a potent and selective tetrodotoxin-resistant Na_v1.8 sodium channel blocker (IC₅₀=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter .

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2

Eact

2 Cited Publications

Cat. No.: HY-103368

CAS No.: 461000-66-8

Purity: 98.86%

Target:

Chloride Channel

Research Areas:

Neurological Disease

Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity .

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2

TLQP-21 TFA

2 Cited Publications

Cat. No.: HY-P1345A

Target:

Complement System

Research Areas:

Neurological Disease Endocrinology

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .

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1

TIP 39, Tuberoinfundibular Neuropeptide

1 Cited Publications

Cat. No.: HY-P1852

CAS No.: 277302-47-3

Target:

Adenylate Cyclase PTHR

Research Areas:

Neurological Disease

TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

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1

AC-55541

1 Cited Publications

Cat. No.: HY-14350

CAS No.: 916170-19-9

Purity: 99.40%

Target:

Protease Activated Receptor (PAR)

Research Areas:

Others

AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC₅₀=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC₅₀ values of 5.9 and 6.6 in PI hydrolysis assays and Ca ²⁺ mobilization assays and exhibits pronociceptive activity in vivo .

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1

Calcitonin gene-related peptide free acid

1 Cited Publications

Cat. No.: HY-P4058

CAS No.: 83652-28-2

Synonyms: CGRP free acid

Target:

CGRP Receptor

Research Areas:

Neurological Disease

Calcitonin gene-related peptide (CGRP) free acid is a 37-amino acid neuropeptide, which represents the deamidated form of α-CGRP (human) (HY-P1071). Calcitonin gene-related peptide free acid is produced in the central and peripheral nervous systems of rats, and localizes to specific sensory, integrative and motor neuron systems, including those involved in nociception/thermoreception, feeding behavior, olfaction and visceral motor functions .

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Citronellal

Cat. No.: HY-N7126

CAS No.: 106-23-0

Category:

Rutaceae Extract Ketones, Aldehydes, Acids 500 - Internal Server Error | MedChemExpress

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