291 Results for "

1A12

" in MedChemExpress (MCE) Product Catalog:
Products (291)

291 Results for "1A12" in MCE Product Catalog:

25
Sphingosine-1-phosphate
Sphingosine-1-phosphate
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25 Publications Verification
Cat. No.: HY-108496
CAS No.: 26993-30-6
Purity:  ≥99.0%
Synonyms: S1P
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Endogenous Metabolite LPL Receptor

Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .
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12
Fenebrutinib
Fenebrutinib
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12 Cited Publications
Cat. No.: HY-19834
CAS No.: 1434048-34-6
Synonyms: GDC-0853
Target:  

Btk

Research Areas:  

Cancer

Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research .
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6
Merestinib dihydrochloride
Merestinib dihydrochloride
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6 Cited Publications
Cat. No.: HY-15514A
CAS No.: 1206801-37-7
Purity:  99.36%
Synonyms: LY2801653 dihydrochloride
Target:  

c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor

Research Areas:  

Cancer

Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .
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6
Merestinib
Merestinib
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6 Cited Publications
Cat. No.: HY-15514
CAS No.: 1206799-15-6
Purity:  98.18%
Synonyms: LY2801653
Target:  

c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor

Research Areas:  

Cancer

Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .
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3
CGP 57380
CGP 57380
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3 Cited Publications
Cat. No.: HY-10520
CAS No.: 522629-08-9
Purity:  98.71%
Target:  

MNK Apoptosis

Research Areas:  

Cancer

CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
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3
1,2-DLPC
1,2-DLPC
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3 Cited Publications
Cat. No.: HY-107737
CAS No.: 18194-25-7
Purity:  ≥98.0%
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine
Target:  

Liposome Apoptosis TNF Receptor PPAR

Research Areas:  

Metabolic Disease

1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells .
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3
TAK-220
TAK-220
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3 Cited Publications
Cat. No.: HY-19974
CAS No.: 333994-00-6
Target:  

CCR HIV

Research Areas:  

Infection Endocrinology

TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.
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2
MRTX0902
MRTX0902
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2 Cited Publications
Cat. No.: HY-145926
CAS No.: 2654743-22-1
Purity:  99.75%
Target:  

SOS1 Ras

Research Areas:  

Neurological Disease Cancer

MRTX0902 is a potent, selective, brain-penetrant, and orally active SOS1 inhibitor with a Ki of 1.9 nM. MRTX0902 disrupts the SOS1:KRASG12C protein-protein interaction (PPI). MRTX0902 can be used in research on pancreatic ductal adenocarcinoma .
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2
Lactate oxidase, Microorganism
Lactate oxidase, Microorganism
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2 Cited Publications
Cat. No.: HY-134757
CAS No.: 9028-72-2
Target:  

Endogenous Metabolite

Research Areas:  

Others

Lactate oxidase (EC 1.13.12.4) belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate .
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2
POLA1 inhibitor 1
POLA1 inhibitor 1
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2 Cited Publications
Cat. No.: HY-147812
CAS No.: 2217671-41-3
Purity:  98.85%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line .
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2
αvβ5 integrin-IN-1
αvβ5 integrin-IN-1
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2 Cited Publications
Cat. No.: HY-145363
CAS No.: 2615912-33-7
Purity:  99.72%
Target:  

Integrin

Research Areas:  

Cancer

αvβ5 integrin-IN-1 (Compound 12) is a selective αvβ5 inhibitor (pIC50 = 8.2). αvβ5 integrin-IN-1 exhibits 800-fold selectivity for αvβ5 versus αvβ3 .
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2
DI-1859
DI-1859
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2 Cited Publications
Cat. No.: HY-145733
CAS No.: 2247061-09-0
Purity:  99.62%
Target:  

E1/E2/E3 Enzyme Keap1-Nrf2 Reactive Oxygen Species (ROS) Insulin Receptor Akt

Research Areas:  

Metabolic Disease Cancer

DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer .
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2
BODIPY 500/510 C1, C12
BODIPY 500/510 C1, C12
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2 Cited Publications
Cat. No.: HY-D1617
CAS No.: 144672-74-2
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20°C.
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1
DI-591
DI-591
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1 Cited Publications
Cat. No.: HY-124602
CAS No.: 2245887-38-9
Purity:  99.42%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members .
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1
CXCL-CXCR1/2-IN-1
CXCL-CXCR1/2-IN-1
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1 Cited Publications
Cat. No.: HY-163475
CAS No.: 2415653-55-1
Target:  

CXCR

Research Areas:  

Cancer

CXCL-CXCR1/2-IN-1 is an orally active ELR +CXCL-CXCR1/2 pathway inhibitor with an EC50 of 42.7 nM for CXCR2 [1]. CXCL-CXCR1/2-IN-1 shows anticancer and antiangiogenic effects .
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1
C12-iE-DAP hydrochloride
C12-iE-DAP hydrochloride
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1 Cited Publications
Cat. No.: HY-P5524A
Synonyms: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride; γ-D-glutamyl-meso-diaminopimelic acid hydrochloride
Target:  

NOD-like Receptor (NLR) p38 MAPK NF-κB Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology Cancer

C12-iE-DAP hydrochloride (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride) is a highly potent and selective NOD1 agonist, with an EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1. C12-iE-DAP hydrochloride activates the NOD1/RIPK2 signaling pathway and its downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling. C12-iE-DAP hydrochloride can be used in studies related to vascular inflammation, tumor metastasis and neuroinflammation .
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Anti-Mouse PD-1 Antibody (29F.1A12)
Anti-Mouse PD-1 Antibody (29F.1A12)
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Cat. No.: HY-P990788

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse PD-1 Antibody (29F.1A12) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-1. Anti-Mouse PD-1 Antibody (29F.1A12) blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2. Anti-Mouse PD-1 Antibody (29F.1A12) can be used for the researches of cancer and immunology, such as CT26 tumor and pancreatic cancer .
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Anti-Mouse IL-2 Antibody (JES6-1A12)
Anti-Mouse IL-2 Antibody (JES6-1A12)
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Cat. No.: HY-P990219

Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology

Anti-Mouse IL-2 Antibody (JES6-1A12) is an anti-mouse IL-2 IgG1 monoclonal antibody. Anti-Mouse IL-2 Antibody (JES6-1A12) can inhibit Treg amplification and enhance Th1 response. Anti-Mouse IL-2 Antibody (JES6-1A12) can form a complex with IL-2 for experimentation. Anti-Mouse IL-2 Antibody (JES6-1A12) can be used for research on infection conditions such as malaria .
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1-Phenylethane-1,2-diol
1-Phenylethane-1,2-diol
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Cat. No.: HY-W015788
CAS No.: 93-56-1
Synonyms: Styrene Glycol
Category:  

Natural Products Microorganisms Other Diseases Disease Research Fields

Target:  

Environmental Pollutants Drug Metabolite Biochemical Assay Reagents

1-Phenylethane-1,2-diol (Styrene Glycol) is a benzyl diol compound, which is the major metabolite of Styrene. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics .
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1-Phenylpropane-1,2-dione
1-Phenylpropane-1,2-dione
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Cat. No.: HY-W018758
CAS No.: 579-07-7
Category:  

Ketones, Aldehydes, Acids Other Diseases Plants Ephedraceae Extract Disease Research Fields 500 - Internal Server Error | MedChemExpress

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