184 Results for "

ADP-ribose

" in MedChemExpress (MCE) Product Catalog:
Products (184)

184 Results for "ADP-ribose" in MCE Product Catalog:

29
PDD 00017273
PDD 00017273
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29 Publications Verification
Cat. No.: HY-108360
CAS No.: 1945950-21-9
Purity:  99.06%
Target:  

Poly(ADP-ribose) Glycohydrolase (PARG)

Research Areas:  

Cancer

PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM .
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21
Floxuridine
Floxuridine
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21 Cited Publications
Cat. No.: HY-B0097
CAS No.: 50-91-9
Synonyms: 5-Fluorouracil 2'-deoxyriboside
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis

Research Areas:  

Infection Cancer

Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .
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9
Adenosine 5′-diphosphoribose sodium
Adenosine 5′-diphosphoribose sodium
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9 Cited Publications
Cat. No.: HY-100973A
CAS No.: 68414-18-6
Purity:  99.47%
Synonyms: ADP ribose sodium
Target:  

TRP Channel Autophagy

Research Areas:  

Metabolic Disease Endocrinology Cancer

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
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9
Adenosine 5′-diphosphoribose
Adenosine 5′-diphosphoribose
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9 Cited Publications
Cat. No.: HY-100973
CAS No.: 20762-30-5
Purity:  98.21%
Synonyms: ADP ribose
Target:  

TRP Channel Autophagy

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .
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8
PARP1 Protein, Human (sf9, His)
PARP1 Protein, Human (sf9, His)
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8 Cited Publications
Cat. No.: HY-P74652
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PARP1; NAD(+) ADP-Ribosyltransferase 1; Prev. ADPRT; Poly[ADP-ribose] Synthase 1; Prev. PPOL; ADPRT 1; ARTD1; PARP-1; Poly-PARP; ADP-Ribosyltransferase NAD(+); PARS; NAD(+) ADP-Ribosyltransferase; PARP; Poly(ADP-Ribosyl)Transferase; ADP-Ribosyltransferase
Species:  
Human
Source:  
Sf9 insect cells
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7
Sulfo-ara-F-NMN
Sulfo-ara-F-NMN
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7 Cited Publications
Cat. No.: HY-129522
CAS No.: 1374663-29-2
Purity:  99.18%
Synonyms: CZ-48
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Neurological Disease

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .
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5
BSJ-4-116
BSJ-4-116
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5 Cited Publications
Cat. No.: HY-139039
CAS No.: 2519823-34-6
Purity:  98.73%
Target:  

PROTACs CDK

Research Areas:  

Cancer

BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162) .
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4
4'-O-Methylbavachalcone
4'-O-Methylbavachalcone
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4 Cited Publications
Cat. No.: HY-N1910
CAS No.: 20784-60-5
Category:  

Infection Flavonoids Chalcones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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