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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
APL
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "APL" in MCE Product Catalog:
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Cat. No.: HY-169322
CAS No.: 2921735-80-8
Synonyms: Mal-Exo-EVC-MMAE
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APL-1081 (Mal-Exo-EVC-MMAE) is a component of the antibody-drug conjugate active molecule ADC. APL-1081 is formed by conjugating the ADC linker (peptide Mal-Exo-EEVC) with the potent tubulin polymerization inhibitor Monomethyl auristatin E (HY-15162). APL-1081 can be used in tumor research .
Cat. No.: HY-175888
CAS No.: 2921735-93-3
Synonyms: Mc-exo-EVC-Exatecan
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APL-1082 is a drug-Linker conjugate that can be used for ADC synthesis. APL-1082 contains Exatecan (HY-13631) and Linker (HY-175929). APL-1082 reduces aggregation and hydrophobicity in Trastuzumab (HY-P9907) ADCs, enables production of high-DAR (10) ADCs with homogeneity and defined physicochemical properties. APL-1082 forms a Trastuzumab ADC with enhanced stability, showing greater DAR retention over time. APL-1082 can be used for the research of gastric cancer .
Cat. No.: HY-P6365
Synonyms: L-4F TFA
APL180 TFA (L-4F TFA) is an Apo-A1 mimetic peptide . APL180 TFA binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 TFA downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 TFA inhibits atherosclerotic lesion progression and platelet aggregation. APL180 TFA attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 TFA can be used for research on ovarian cancer .
Cat. No.: HY-169323
CAS No.: 2921735-87-5
Synonyms: Mal-Exo-EEVC-MMAE
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APL-1091 (Mal-Exo-EEVC-MMAE) is an ADC payload-linker conjugate (Drug-Linker Conjugates for ADC). APL-1091 is formed by the conjugation of the Mal-Exo-EEVC (HY-169353) linker and MMAE (HY-15162), a microtubule inhibitor. APL-1091 resists aggregation at high drug-to-antibody ratio (DAR), exhibits excellent plasma stability, and reduces premature payload release. When conjugated with Trastuzumab (HY-P9907), APL-1091 displays anti-tumor activity in gastric cancer xenograft models. APL-1091 can be used for ADC synthesis and gastric cancer-related research .
Cat. No.: HY-178980
CAS No.: 2830619-57-1
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APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer .
Cat. No.: HY-P1996
CAS No.: 178823-49-9
Synonyms: NBI-5788
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Cat. No.: HY-169324
CAS No.: 2921735-91-1
Synonyms: Mal-Exo-EEVC-Exatecan
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APL-1092 is an EEVC linker-payload conjugate composed of exatecan, a stabilizer that prevents premature payload release, and a cleavage substrate for cathepsin B . APL-1092 resists premature payload release mediated by human neutrophil elastase and carboxylesterase, maintains payload stability in mouse plasma, and retains cathepsin B-mediated cleavage activity in target cells . APL-1092 exhibits dose-dependent tumor growth inhibition in xenograft mice . APL-1092 can be used in gastric cancer-related research .
Cat. No.: HY-P6365A
CAS No.: 388566-97-0
Synonyms: L-4F
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APL180 (L-4F) is an Apo-A1 mimetic peptide . APL180 binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 inhibits atherosclerotic lesion progression and platelet aggregation. APL180 attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 can be used for research on ovarian cancer .
Cat. No.: HY-P99639
CAS No.: 2348469-43-0
Synonyms: Genolimzumab; APL-501; CBT-501; GB-226
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Cat. No.: HY-N15852
CAS No.: 3056014-15-1
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APL-719 is a cationic lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Cat. No.: HY-D0153
CAS No.: 80724-19-2
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Cat. No.: HY-W856819
CAS No.: 469-22-7
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Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease .
Cat. No.: HY-RS18959
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Neu1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Neu1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-106171
CAS No.: 239480-61-6
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Cat. No.: HY-181959
CAS No.: 2752441-61-3
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APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. APL-4098 reduces the phosphorylation level of eIF2α and the expression level of ATF4. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia .
Cat. No.: HY-N15802
CAS No.: 3056014-13-9
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APL-718 chloride is a fixed cationic lipid.
Cat. No.: HY-A0009S
Synonyms: Galantamine-d3 hydrobromide
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
