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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
APOC3 mRNA
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "APOC3 mRNA" in MCE Product Catalog:
Cat. No.: HY-164740
CAS No.: 2379776-40-4
Synonyms: ARO-APOC3
Research Areas:
Plozasiran (ARO-APOC3) is a siRNA targeting APOC3. Plozasiran mediates RNA interference-mediated degradation and silencing of APOC3 mRNA, reducing APOC3 synthesis and expression, apoC3 protein expression, and plasma ApoC3 concentrations. Plozasiran reduces fasting and non-fasting plasma triglyceride concentrations in diet-induced hypertriglyceridemia. Plozasiran can be used in research on hypertriglyceridemia, mixed hyperlipidemia, and mixed dyslipidemia .
Cat. No.: HY-153491
CAS No.: 2097587-83-0
Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
Cat. No.: HY-164740A
CAS No.: 2379776-41-5
Synonyms: ARO-APOC3 sodium
Research Areas:
Plozasiran sodium (ARO-APOC3 sodium) is a siRNA targeting APOC3. Plozasiran sodium mediates RNA interference-mediated degradation and silencing of APOC3 mRNA, reducing APOC3 synthesis and expression, apoC3 protein expression, and plasma ApoC3 concentrations. Plozasiran sodium reduces fasting and non-fasting plasma triglyceride concentrations in diet-induced hypertriglyceridemia. Plozasiran sodium can be used in research on hypertriglyceridemia, mixed hyperlipidemia, and mixed dyslipidemia .
Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
